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Journal of Bacteriology, December 2003, p. 6990-6994, Vol. 185, No. 23
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.23.6990-6994.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Slipped-Strand Mispairing Can Function as a Phase Variation Mechanism in Escherichia coli

Joshua Torres-Cruz and Marjan W. van der Woude*

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Received 6 June 2003/ Accepted 10 September 2003

Slipped-strand mispairing (SSM) has not been identified as a mechanism of phase variation in Escherichia coli. Using a reporter gene, we show that sequences that cause phase variation by SSM in Haemophilus influenzae also lead to phase variation when introduced onto the chromosome of E. coli, and the frequencies of switching are in the biologically relevant range. Thus, the absence of SSM-mediated phase variation in E. coli does not appear to be due to a mechanistic constraint.

* Corresponding author. Mailing address: Department of Microbiology, University of Pennsylvania, 202A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076. Phone: (215) 573-4104. Fax: (215) 573-4184. E-mail: mvdwoude{at}mail.med.upenn.edu.

Journal of Bacteriology, December 2003, p. 6990-6994, Vol. 185, No. 23
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.23.6990-6994.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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