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Journal of Bacteriology, December 2003, p. 7291-7296, Vol. 185, No. 24
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.24.7291-7296.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Colonial Differentiation in Streptomyces coelicolor Depends on Translation of a Specific Codon within the adpA Gene

Kien T. Nguyen,{dagger} Jennifer Tenor, Hansruedi Stettler, Lieu T. Nguyen, Liem D. Nguyen, and Charles J. Thompson*

Department of Molecular Microbiology, Biozentrum, Universität Basel, 4056 Basel, Switzerland

Received 28 August 2003/ Accepted 4 September 2003

We identified adpA as an araC-like regulatory gene needed for colonial morphogenesis in Streptomyces coelicolor and showed that its activity depended on a unique TTA triplet corresponding to the leucyl-tRNA gene (bldA). These findings partially explained the dependence of aerial mycelium formation on a rare tRNA that is postulated to have developmental control functions.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Biozentrum, Universität Basel, Klingelbergstr. 50/70, 4056 Basel, Switzerland. Phone: 41 61 267 2116. Fax: 41 61 267 2118. E-mail: Charles-J.Thompson{at}unibas.ch.

{dagger} Present address: Cubist Pharmaceuticals, 65 Hayden Ave., Lexington, MA 02421.

Journal of Bacteriology, December 2003, p. 7291-7296, Vol. 185, No. 24
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.24.7291-7296.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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