This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schuster, M.
Right arrow Articles by Greenberg, E. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schuster, M.
Right arrow Articles by Greenberg, E. P.

 Previous Article  |  Next Article 

Journal of Bacteriology, April 2003, p. 2066-2079, Vol. 185, No. 7
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.7.2066-2079.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis{dagger}

Martin Schuster,1 C. Phoebe Lostroh,1 Tomoo Ogi,2 and E. P. Greenberg1*

Department of Microbiology and W. M. Keck Microbial Communities and Cell Signaling Program, University of Iowa, Iowa City, Iowa 52242,1 Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom2

Received 30 August 2002/ Accepted 5 December 2002

There are two interrelated acyl-homoserine lactone quorum-sensing-signaling systems in Pseudomonas aeruginosa. These systems, the LasR-LasI system and the RhlR-RhlI system, are global regulators of gene expression. We performed a transcriptome analysis to identify quorum-sensing-controlled genes and to better understand quorum-sensing control of P. aeruginosa gene expression. We compared gene expression in a LasI-RhlI signal mutant grown with added signals to gene expression without added signals, and we compared a LasR-RhlR signal receptor mutant to its parent. In all, we identified 315 quorum-induced and 38 quorum-repressed genes, representing about 6% of the P. aeruginosa genome. The quorum-repressed genes were activated in the stationary phase in quorum-sensing mutants but were not activated in the parent strain. The analysis of quorum-induced genes suggests that the signal specificities are on a continuum and that the timing of gene expression is on a continuum (some genes are induced early in growth, most genes are induced at the transition from the logarithmic phase to the stationary phase, and some genes are induced during the stationary phase). In general, timing was not related to signal concentration. We suggest that the level of the signal receptor, LasR, is a critical trigger for quorum-activated gene expression. Acyl-homoserine lactone quorum sensing appears to be a system that allows ordered expression of hundreds of genes during P. aeruginosa growth in culture.

* Corresponding author. Mailing address: 540 EMRB, Newton Road, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, IA 52242. Phone: (319) 335-7775. Fax: (319) 335-7949. E-mail: Everett-greenberg{at}uiowa.edu.

{dagger} For a commentary on this article, see page 2061 in this issue.

Journal of Bacteriology, April 2003, p. 2066-2079, Vol. 185, No. 7
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.7.2066-2079.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ghosh, D., Roy, K., Williamson, K. E., Srinivasiah, S., Wommack, K. E., Radosevich, M. (2009). Acyl-Homoserine Lactones Can Induce Virus Production in Lysogenic Bacteria: an Alternative Paradigm for Prophage Induction. Appl. Environ. Microbiol. 75: 7142-7152 [Abstract] [Full Text]  
  • Khajanchi, B. K., Sha, J., Kozlova, E. V., Erova, T. E., Suarez, G., Sierra, J. C., Popov, V. L., Horneman, A. J., Chopra, A. K. (2009). N-Acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila. Microbiology 155: 3518-3531 [Abstract] [Full Text]  
  • Tian, Z.-X., Fargier, E., Mac Aogain, M., Adams, C., Wang, Y.-P., O'Gara, F. (2009). Transcriptome profiling defines a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa. Nucleic Acids Res 0: gkp828v1-gkp828 [Abstract] [Full Text]  
  • Boulette, M. L., Baynham, P. J., Jorth, P. A., Kukavica-Ibrulj, I., Longoria, A., Barrera, K., Levesque, R. C., Whiteley, M. (2009). Characterization of Alanine Catabolism in Pseudomonas aeruginosa and Its Importance for Proliferation In Vivo. J. Bacteriol. 191: 6329-6334 [Abstract] [Full Text]  
  • Chandler, J. R., Duerkop, B. A., Hinz, A., West, T. E., Herman, J. P., Churchill, M. E. A., Skerrett, S. J., Greenberg, E. P. (2009). Mutational Analysis of Burkholderia thailandensis Quorum Sensing and Self-Aggregation. J. Bacteriol. 191: 5901-5909 [Abstract] [Full Text]  
  • Gupta, R., Gobble, T. R., Schuster, M. (2009). GidA Posttranscriptionally Regulates rhl Quorum Sensing in Pseudomonas aeruginosa. J. Bacteriol. 191: 5785-5792 [Abstract] [Full Text]  
  • Lesic, B., Starkey, M., He, J., Hazan, R., Rahme, L. G. (2009). Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis. Microbiology 155: 2845-2855 [Abstract] [Full Text]  
  • Steindler, L., Bertani, I., De Sordi, L., Schwager, S., Eberl, L., Venturi, V. (2009). LasI/R and RhlI/R Quorum Sensing in a Strain of Pseudomonas aeruginosa Beneficial to Plants. Appl. Environ. Microbiol. 75: 5131-5140 [Abstract] [Full Text]  
  • Lopez, D., Vlamakis, H., Losick, R., Kolter, R. (2009). Paracrine signaling in a bacterium. Genes Dev. 23: 1631-1638 [Abstract] [Full Text]  
  • Gurich, N., Gonzalez, J. E. (2009). Role of Quorum Sensing in Sinorhizobium meliloti-Alfalfa Symbiosis. J. Bacteriol. 191: 4372-4382 [Abstract] [Full Text]  
  • Mashburn-Warren, L., Howe, J., Brandenburg, K., Whiteley, M. (2009). Structural Requirements of the Pseudomonas Quinolone Signal for Membrane Vesicle Stimulation. J. Bacteriol. 191: 3411-3414 [Abstract] [Full Text]  
  • Kohler, T., Buckling, A., van Delden, C. (2009). Cooperation and virulence of clinical Pseudomonas aeruginosa populations. Proc. Natl. Acad. Sci. USA 106: 6339-6344 [Abstract] [Full Text]  
  • Sarnovsky, R., Rea, J., Makowski, M., Hertle, R., Kelly, C., Antignani, A., Pastrana, D. V., FitzGerald, D. J. (2009). Proteolytic Cleavage of a C-terminal Prosequence, Leading to Autoprocessing at the N Terminus, Activates Leucine Aminopeptidase from Pseudomonas aeruginosa. J. Biol. Chem. 284: 10243-10253 [Abstract] [Full Text]  
  • Damron, F. H., Napper, J., Teter, M. A., Yu, H. D. (2009). Lipotoxin F of Pseudomonas aeruginosa is an AlgU-dependent and alginate-independent outer membrane protein involved in resistance to oxidative stress and adhesion to A549 human lung epithelia. Microbiology 155: 1028-1038 [Abstract] [Full Text]  
  • Bernard, C. S., Bordi, C., Termine, E., Filloux, A., de Bentzmann, S. (2009). Organization and PprB-Dependent Control of the Pseudomonas aeruginosa tad Locus, Involved in Flp Pilus Biology. J. Bacteriol. 191: 1961-1973 [Abstract] [Full Text]  
  • Mikkelsen, H., Bond, N. J., Skindersoe, M. E., Givskov, M., Lilley, K. S., Welch, M. (2009). Biofilms and type III secretion are not mutually exclusive in Pseudomonas aeruginosa. Microbiology 155: 687-698 [Abstract] [Full Text]  
  • Dekimpe, V., Deziel, E. (2009). Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors. Microbiology 155: 712-723 [Abstract] [Full Text]  
  • Ramsey, M. M., Whiteley, M. (2009). Polymicrobial interactions stimulate resistance to host innate immunity through metabolite perception. Proc. Natl. Acad. Sci. USA 106: 1578-1583 [Abstract] [Full Text]  
  • Manos, J., Arthur, J., Rose, B., Tingpej, P., Fung, C., Curtis, M., Webb, J. S., Hu, H., Kjelleberg, S., Gorrell, M. D., Bye, P., Harbour, C. (2008). Transcriptome analyses and biofilm-forming characteristics of a clonal Pseudomonas aeruginosa from the cystic fibrosis lung. J Med Microbiol 57: 1454-1465 [Abstract] [Full Text]  
  • Sugimura, M., Maseda, H., Hanaki, H., Nakae, T. (2008). Macrolide Antibiotic-Mediated Downregulation of MexAB-OprM Efflux Pump Expression in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 52: 4141-4144 [Abstract] [Full Text]  
  • Farrow, J. M. III, Sund, Z. M., Ellison, M. L., Wade, D. S., Coleman, J. P., Pesci, E. C. (2008). PqsE Functions Independently of PqsR-Pseudomonas Quinolone Signal and Enhances the rhl Quorum-Sensing System. J. Bacteriol. 190: 7043-7051 [Abstract] [Full Text]  
  • Tarighi, S., Wei, Q., Camara, M., Williams, P., Fletcher, M. P., Kajander, T., Cornelis, P. (2008). The PA4204 gene encodes a periplasmic gluconolactonase (PpgL) which is important for fitness of Pseudomonas aeruginosa. Microbiology 154: 2979-2990 [Abstract] [Full Text]  
  • Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, T., Tolker-Nielsen, T., Hoiby, N., Givskov, M. (2008). Effects of Antibiotics on Quorum Sensing in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 52: 3648-3663 [Abstract] [Full Text]  
  • Upritchard, H. G., Cordwell, S. J., Lamont, I. L. (2008). Immunoproteomics To Examine Cystic Fibrosis Host Interactions with Extracellular Pseudomonas aeruginosa Proteins. Infect. Immun. 76: 4624-4632 [Abstract] [Full Text]  
  • Liang, H., Li, L., Dong, Z., Surette, M. G., Duan, K. (2008). The YebC Family Protein PA0964 Negatively Regulates the Pseudomonas aeruginosa Quinolone Signal System and Pyocyanin Production. J. Bacteriol. 190: 6217-6227 [Abstract] [Full Text]  
  • Overhage, J., Campisano, A., Bains, M., Torfs, E. C. W., Rehm, B. H. A., Hancock, R. E. W. (2008). Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation. Infect. Immun. 76: 4176-4182 [Abstract] [Full Text]  
  • Willcox, M. D. P., Zhu, H., Conibear, T. C. R., Hume, E. B. H., Givskov, M., Kjelleberg, S., Rice, S. A. (2008). Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis. Microbiology 154: 2184-2194 [Abstract] [Full Text]  
  • Kiely, P. D., O'Callaghan, J., Abbas, A., O'Gara, F. (2008). Genetic analysis of genes involved in dipeptide metabolism and cytotoxicity in Pseudomonas aeruginosa PAO1. Microbiology 154: 2209-2218 [Abstract] [Full Text]  
  • Lenz, A. P., Williamson, K. S., Pitts, B., Stewart, P. S., Franklin, M. J. (2008). Localized Gene Expression in Pseudomonas aeruginosa Biofilms. Appl. Environ. Microbiol. 74: 4463-4471 [Abstract] [Full Text]  
  • Kukavica-Ibrulj, I., Sanschagrin, F., Peterson, A., Whiteley, M., Boyle, B., MacKay, J., Levesque, R. C. (2008). Functional genomics of PycR, a LysR family transcriptional regulator essential for maintenance of Pseudomonas aeruginosa in the rat lung. Microbiology 154: 2106-2118 [Abstract] [Full Text]  
  • Takaya, A., Tabuchi, F., Tsuchiya, H., Isogai, E., Yamamoto, T. (2008). Negative Regulation of Quorum-Sensing Systems in Pseudomonas aeruginosa by ATP-Dependent Lon Protease. J. Bacteriol. 190: 4181-4188 [Abstract] [Full Text]  
  • Oglesby, A. G., Farrow, J. M. III, Lee, J.-H., Tomaras, A. P., Greenberg, E. P., Pesci, E. C., Vasil, M. L. (2008). The Influence of Iron on Pseudomonas aeruginosa Physiology: A REGULATORY LINK BETWEEN IRON AND QUORUM SENSING. J. Biol. Chem. 283: 15558-15567 [Abstract] [Full Text]  
  • Overhage, J., Bains, M., Brazas, M. D., Hancock, R. E. W. (2008). Swarming of Pseudomonas aeruginosa Is a Complex Adaptation Leading to Increased Production of Virulence Factors and Antibiotic Resistance. J. Bacteriol. 190: 2671-2679 [Abstract] [Full Text]  
  • Ravantti, J. J., Ruokoranta, T. M., Alapuranen, A. M., Bamford, D. H. (2008). Global Transcriptional Responses of Pseudomonas aeruginosa to Phage PRR1 Infection. J. Virol. 82: 2324-2329 [Abstract] [Full Text]  
  • Rao, J., DiGiandomenico, A., Unger, J., Bao, Y., Polanowska-Grabowska, R. K., Goldberg, J. B. (2008). A novel oxidized low-density lipoprotein-binding protein from Pseudomonas aeruginosa. Microbiology 154: 654-665 [Abstract] [Full Text]  
  • Baert, B., Baysse, C., Matthijs, S., Cornelis, P. (2008). Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa. Microbiology 154: 127-138 [Abstract] [Full Text]  
  • Sztajer, H., Lemme, A., Vilchez, R., Schulz, S., Geffers, R., Yip, C. Y. Y., Levesque, C. M., Cvitkovitch, D. G., Wagner-Dobler, I. (2008). Autoinducer-2-Regulated Genes in Streptococcus mutans UA159 and Global Metabolic Effect of the luxS Mutation. J. Bacteriol. 190: 401-415 [Abstract] [Full Text]  
  • Yarwood, J. M., Paquette, K. M., Tikh, I. B., Volper, E. M., Greenberg, E. P. (2007). Generation of Virulence Factor Variants in Staphylococcus aureus Biofilms. J. Bacteriol. 189: 7961-7967 [Abstract] [Full Text]  
  • Kirisits, M. J., Margolis, J. J., Purevdorj-Gage, B. L., Vaughan, B., Chopp, D. L., Stoodley, P., Parsek, M. R. (2007). Influence of the Hydrodynamic Environment on Quorum Sensing in Pseudomonas aeruginosa Biofilms. J. Bacteriol. 189: 8357-8360 [Abstract] [Full Text]  
  • Antunes, L. C. M., Schaefer, A. L., Ferreira, R. B. R., Qin, N., Stevens, A. M., Ruby, E. G., Greenberg, E. P. (2007). Transcriptome Analysis of the Vibrio fischeri LuxR-LuxI Regulon. J. Bacteriol. 189: 8387-8391 [Abstract] [Full Text]  
  • Palmer, K. L., Aye, L. M., Whiteley, M. (2007). Nutritional Cues Control Pseudomonas aeruginosa Multicellular Behavior in Cystic Fibrosis Sputum. J. Bacteriol. 189: 8079-8087 [Abstract] [Full Text]  
  • Patrauchan, M. A., Sarkisova, S. A., Franklin, M. J. (2007). Strain-specific proteome responses of Pseudomonas aeruginosa to biofilm-associated growth and to calcium. Microbiology 153: 3838-3851 [Abstract] [Full Text]  
  • Son, M. S., Matthews, W. J. Jr., Kang, Y., Nguyen, D. T., Hoang, T. T. (2007). In Vivo Evidence of Pseudomonas aeruginosa Nutrient Acquisition and Pathogenesis in the Lungs of Cystic Fibrosis Patients. Infect. Immun. 75: 5313-5324 [Abstract] [Full Text]  
  • Morici, L. A., Carterson, A. J., Wagner, V. E., Frisk, A., Schurr, J. R., zu Bentrup, K. H., Hassett, D. J., Iglewski, B. H., Sauer, K., Schurr, M. J. (2007). Pseudomonas aeruginosa AlgR Represses the Rhl Quorum-Sensing System in a Biofilm-Specific Manner. J. Bacteriol. 189: 7752-7764 [Abstract] [Full Text]  
  • Sandoz, K. M., Mitzimberg, S. M., Schuster, M. (2007). From the Cover: Social cheating in Pseudomonas aeruginosa quorum sensing. Proc. Natl. Acad. Sci. USA 104: 15876-15881 [Abstract] [Full Text]  
  • Lequette, Y., Rollet, E., Delangle, A., Greenberg, E. P., Bohin, J.-P. (2007). Linear osmoregulated periplasmic glucans are encoded by the opgGH locus of Pseudomonas aeruginosa. Microbiology 153: 3255-3263 [Abstract] [Full Text]  
  • Brown, S. A., Whiteley, M. (2007). A Novel Exclusion Mechanism for Carbon Resource Partitioning in Aggregatibacter actinomycetemcomitans. J. Bacteriol. 189: 6407-6414 [Abstract] [Full Text]  
  • Williams, P., Winzer, K., Chan, W. C, Camara, M. (2007). Look who's talking: communication and quorum sensing in the bacterial world. Phil Trans R Soc B 362: 1119-1134 [Abstract] [Full Text]  
  • Barnard, A. M.L, Bowden, S. D, Burr, T., Coulthurst, S. J, Monson, R. E, Salmond, G. P.C (2007). Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria. Phil Trans R Soc B 362: 1165-1183 [Abstract] [Full Text]  
  • Bjarnsholt, T., Givskov, M. (2007). Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. Phil Trans R Soc B 362: 1213-1222 [Abstract] [Full Text]  
  • Duan, K., Surette, M. G. (2007). Environmental Regulation of Pseudomonas aeruginosa PAO1 Las and Rhl Quorum-Sensing Systems. J. Bacteriol. 189: 4827-4836 [Abstract] [Full Text]  
  • Toyofuku, M., Nomura, N., Fujii, T., Takaya, N., Maseda, H., Sawada, I., Nakajima, T., Uchiyama, H. (2007). Quorum Sensing Regulates Denitrification in Pseudomonas aeruginosa PAO1. J. Bacteriol. 189: 4969-4972 [Abstract] [Full Text]  
  • Li, L.-L., Malone, J. E., Iglewski, B. H. (2007). Regulation of the Pseudomonas aeruginosa Quorum-Sensing Regulator VqsR. J. Bacteriol. 189: 4367-4374 [Abstract] [Full Text]  
  • Michel, G. P. F., Durand, E., Filloux, A. (2007). XphA/XqhA, a Novel GspCD Subunit for Type II Secretion in Pseudomonas aeruginosa. J. Bacteriol. 189: 3776-3783 [Abstract] [Full Text]  
  • Ishida, T., Ikeda, T., Takiguchi, N., Kuroda, A., Ohtake, H., Kato, J. (2007). Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N-Acyl Cyclopentylamides. Appl. Environ. Microbiol. 73: 3183-3188 [Abstract] [Full Text]  
  • Bottomley, M. J., Muraglia, E., Bazzo, R., Carfi, A. (2007). Molecular Insights into Quorum Sensing in the Human Pathogen Pseudomonas aeruginosa from the Structure of the Virulence Regulator LasR Bound to Its Autoinducer. J. Biol. Chem. 282: 13592-13600 [Abstract] [Full Text]  
  • Jensen, P. O., Bjarnsholt, T., Phipps, R., Rasmussen, T. B., Calum, H., Christoffersen, L., Moser, C., Williams, P., Pressler, T., Givskov, M., Hoiby, N. (2007). Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa. Microbiology 153: 1329-1338 [Abstract] [Full Text]  
  • Farrow, J. M. III, Pesci, E. C. (2007). Two Distinct Pathways Supply Anthranilate as a Precursor of the Pseudomonas Quinolone Signal. J. Bacteriol. 189: 3425-3433 [Abstract] [Full Text]  
  • Stoltz, D. A., Ozer, E. A., Ng, C. J., Yu, J. M., Reddy, S. T., Lusis, A. J., Bourquard, N., Parsek, M. R., Zabner, J., Shih, D. M. (2007). Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L852-L860 [Abstract] [Full Text]  
  • Rey, F. E., Heiniger, E. K., Harwood, C. S. (2007). Redirection of Metabolism for Biological Hydrogen Production. Appl. Environ. Microbiol. 73: 1665-1671 [Abstract] [Full Text]  
  • Subsin, B., Chambers, C. E., Visser, M. B., Sokol, P. A. (2007). Identification of Genes Regulated by the cepIR Quorum-Sensing System in Burkholderia cenocepacia by High-Throughput Screening of a Random Promoter Library. J. Bacteriol. 189: 968-979 [Abstract] [Full Text]  
  • Yan, A., Huang, X., Liu, H., Dong, D., Zhang, D., Zhang, X., Xu, Y. (2007). An rhl-like quorum-sensing system negatively regulates pyoluteorin production in Pseudomonas sp. M18. Microbiology 153: 16-28 [Abstract] [Full Text]  
  • Lujan, A. M., Moyano, A. J., Segura, I., Argarana, C. E., Smania, A. M. (2007). Quorum-sensing-deficient (lasR) mutants emerge at high frequency from a Pseudomonas aeruginosa mutS strain. Microbiology 153: 225-237 [Abstract] [Full Text]  
  • Jensen, V., Lons, D., Zaoui, C., Bredenbruch, F., Meissner, A., Dieterich, G., Munch, R., Haussler, S. (2006). RhlR Expression in Pseudomonas aeruginosa Is Modulated by the Pseudomonas Quinolone Signal via PhoB-Dependent and -Independent Pathways. J. Bacteriol. 188: 8601-8606 [Abstract] [Full Text]  
  • Muh, U., Hare, B. J., Duerkop, B. A., Schuster, M., Hanzelka, B. L., Heim, R., Olson, E. R., Greenberg, E. P. (2006). A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal. Proc. Natl. Acad. Sci. USA 103: 16948-16952 [Abstract] [Full Text]  
  • Barraud, N., Hassett, D. J., Hwang, S.-H., Rice, S. A., Kjelleberg, S., Webb, J. S. (2006). Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa.. J. Bacteriol. 188: 7344-7353 [Abstract] [Full Text]  
  • Muh, U., Schuster, M., Heim, R., Singh, A., Olson, E. R., Greenberg, E. P. (2006). Novel Pseudomonas aeruginosa Quorum-Sensing Inhibitors Identified in an Ultra-High-Throughput Screen. Antimicrob. Agents Chemother. 50: 3674-3679 [Abstract] [Full Text]  
  • Zimmermann, S., Wagner, C., Muller, W., Brenner-Weiss, G., Hug, F., Prior, B., Obst, U., Hansch, G. M. (2006). Induction of neutrophil chemotaxis by the quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone.. Infect. Immun. 74: 5687-5692 [Abstract] [Full Text]  
  • Waters, C. M., Bassler, B. L. (2006). The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers. Genes Dev. 20: 2754-2767 [Abstract] [Full Text]  
  • Laskowski, M. A., Kazmierczak, B. I. (2006). Mutational Analysis of RetS, an Unusual Sensor Kinase-Response Regulator Hybrid Required for Pseudomonas aeruginosa Virulence.. Infect. Immun. 74: 4462-4473 [Abstract] [Full Text]  
  • de Bentzmann, S., Aurouze, M., Ball, G., Filloux, A. (2006). FppA, a Novel Pseudomonas aeruginosa Prepilin Peptidase Involved in Assembly of Type IVb Pili. J. Bacteriol. 188: 4851-4860 [Abstract] [Full Text]  
  • Xiao, G., He, J., Rahme, L. G. (2006). Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry. Microbiology 152: 1679-1686 [Abstract] [Full Text]  
  • Smith, E. E., Buckley, D. G., Wu, Z., Saenphimmachak, C., Hoffman, L. R., D'Argenio, D. A., Miller, S. I., Ramsey, B. W., Speert, D. P., Moskowitz, S. M., Burns, J. L., Kaul, R., Olson, M. V. (2006). From the Cover: Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc. Natl. Acad. Sci. USA 103: 8487-8492 [Abstract] [Full Text]  
  • Nalca, Y., Jansch, L., Bredenbruch, F., Geffers, R., Buer, J., Haussler, S. (2006). Quorum-Sensing Antagonistic Activities of Azithromycin in Pseudomonas aeruginosa PAO1: a Global Approach.. Antimicrob. Agents Chemother. 50: 1680-1688 [Abstract] [Full Text]  
  • Fuqua, C. (2006). The QscR Quorum-Sensing Regulon of Pseudomonas aeruginosa: an Orphan Claims Its Identity. J. Bacteriol. 188: 3169-3171 [Full Text]  
  • Lequette, Y., Lee, J.-H., Ledgham, F., Lazdunski, A., Greenberg, E. P. (2006). A Distinct QscR Regulon in the Pseudomonas aeruginosa Quorum-Sensing Circuit. J. Bacteriol. 188: 3365-3370 [Abstract] [Full Text]  
  • Aspedon, A., Palmer, K., Whiteley, M. (2006). Microarray Analysis of the Osmotic Stress Response in Pseudomonas aeruginosa.. J. Bacteriol. 188: 2721-2725 [Abstract] [Full Text]  
  • Babu, M. M., Priya, M. L., Selvan, A. T., Madera, M., Gough, J., Aravind, L., Sankaran, K. (2006). A Database of Bacterial Lipoproteins (DOLOP) with Functional Assignments to Predicted Lipoproteins.. J. Bacteriol. 188: 2761-2773 [Abstract] [Full Text]  
  • Rasmussen, T. B., Givskov, M. (2006). Quorum sensing inhibitors: a bargain of effects.. Microbiology 152: 895-904 [Abstract] [Full Text]  
  • An, D., Danhorn, T., Fuqua, C., Parsek, M. R. (2006). Quorum sensing and motility mediate interactions between Pseudomonas aeruginosa and Agrobacterium tumefaciens in biofilm cocultures.. Proc. Natl. Acad. Sci. USA 103: 3828-3833 [Abstract] [Full Text]  
  • Sio, C. F., Otten, L. G., Cool, R. H., Diggle, S. P., Braun, P. G., Bos, R., Daykin, M., Camara, M., Williams, P., Quax, W. J. (2006). Quorum Quenching by an N-Acyl-Homoserine Lactone Acylase from Pseudomonas aeruginosa PAO1. Infect. Immun. 74: 1673-1682 [Abstract] [Full Text]  
  • Camilli, A., Bassler, B. L. (2006). Bacterial small-molecule signaling pathways.. Science 311: 1113-1116 [Abstract] [Full Text]  
  • Yang, S., Lopez, C. R., Zechiedrich, E. L. (2006). Quorum sensing and multidrug transporters in Escherichia coli. Proc. Natl. Acad. Sci. USA 103: 2386-2391 [Abstract] [Full Text]  
  • Huang, J. J., Petersen, A., Whiteley, M., Leadbetter, J. R. (2006). Identification of QuiP, the Product of Gene PA1032, as the Second Acyl-Homoserine Lactone Acylase of Pseudomonas aeruginosa PAO1. Appl. Environ. Microbiol. 72: 1190-1197 [Abstract] [Full Text]  
  • Gould, T. A., Herman, J., Krank, J., Murphy, R. C., Churchill, M. E. A. (2006). Specificity of Acyl-Homoserine Lactone Synthases Examined by Mass Spectrometry. J. Bacteriol. 188: 773-783 [Abstract] [Full Text]  
  • Rampioni, G., Bertani, I., Zennaro, E., Polticelli, F., Venturi, V., Leoni, L. (2006). The Quorum-Sensing Negative Regulator RsaL of Pseudomonas aeruginosa Binds to the lasI Promoter. J. Bacteriol. 188: 815-819 [Abstract] [Full Text]  
  • Gao, M., Chen, H., Eberhard, A., Gronquist, M. R., Robinson, J. B., Rolfe, B. G., Bauer, W. D. (2005). sinI- and expR-Dependent Quorum Sensing in Sinorhizobium meliloti. J. Bacteriol. 187: 7931-7944 [Abstract] [Full Text]  
  • Southey-Pillig, C. J., Davies, D. G., Sauer, K. (2005). Characterization of Temporal Protein Production in Pseudomonas aeruginosa Biofilms. J. Bacteriol. 187: 8114-8126 [Abstract] [Full Text]  
  • Wu, M., Guina, T., Brittnacher, M., Nguyen, H., Eng, J., Miller, S. I. (2005). The Pseudomonas aeruginosa Proteome during Anaerobic Growth. J. Bacteriol. 187: 8185-8190 [Abstract] [Full Text]  
  • Farah, C., Vera, M., Morin, D., Haras, D., Jerez, C. A., Guiliani, N. (2005). Evidence for a Functional Quorum-Sensing Type AI-1 System in the Extremophilic Bacterium Acidithiobacillus ferrooxidans. Appl. Environ. Microbiol. 71: 7033-7040 [Abstract] [Full Text]  
  • Koch, B., Liljefors, T., Persson, T., Nielsen, J., Kjelleberg, S., Givskov, M. (2005). The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors. Microbiology 151: 3589-3602 [Abstract] [Full Text]  
  • Hickman, J. W., Tifrea, D. F., Harwood, C. S. (2005). A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels. Proc. Natl. Acad. Sci. USA 102: 14422-14427 [Abstract] [Full Text]  
  • Waite, R. D., Papakonstantinopoulou, A., Littler, E., Curtis, M. A. (2005). Transcriptome Analysis of Pseudomonas aeruginosa Growth: Comparison of Gene Expression in Planktonic Cultures and Developing and Mature Biofilms. J. Bacteriol. 187: 6571-6576 [Abstract] [Full Text]  
  • Visick, K. L., Fuqua, C. (2005). Decoding Microbial Chatter: Cell-Cell Communication in Bacteria. J. Bacteriol. 187: 5507-5519 [Full Text]  
  • Kirisits, M. J., Prost, L., Starkey, M., Parsek, M. R. (2005). Characterization of Colony Morphology Variants Isolated from Pseudomonas aeruginosa Biofilms. Appl. Environ. Microbiol. 71: 4809-4821 [Abstract] [Full Text]  
  • Malott, R. J., Baldwin, A., Mahenthiralingam, E., Sokol, P. A. (2005). Characterization of the cciIR Quorum-Sensing System in Burkholderia cenocepacia. Infect. Immun. 73: 4982-4992 [Abstract] [Full Text]  
  • Palmer, K. L., Mashburn, L. M., Singh, P. K., Whiteley, M. (2005). Cystic Fibrosis Sputum Supports Growth and Cues Key Aspects of Pseudomonas aeruginosa Physiology. J. Bacteriol. 187: 5267-5277 [Abstract] [Full Text]  
  • Heurlier, K., Denervaud, V., Haenni, M., Guy, L., Krishnapillai, V., Haas, D. (2005). Quorum-Sensing-Negative (lasR) Mutants of Pseudomonas aeruginosa Avoid Cell Lysis and Death. J. Bacteriol. 187: 4875-4883 [Abstract] [Full Text]  
  • Salunkhe, P., Smart, C. H. M., Morgan, J. A. W., Panagea, S., Walshaw, M. J., Hart, C. A., Geffers, R., Tummler, B., Winstanley, C. (2005). A Cystic Fibrosis Epidemic Strain of Pseudomonas aeruginosa Displays Enhanced Virulence and Antimicrobial Resistance. J. Bacteriol. 187: 4908-4920 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»