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Journal of Bacteriology, April 2003, p. 2330-2337, Vol. 185, No. 7
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.7.2330-2337.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Comparative Genomics of Salmonella enterica Serovar Typhi Strains Ty2 and CT18{dagger}

Wen Deng,1 Shian-Ren Liou,1,{ddagger} Guy Plunkett III,1 George F. Mayhew,1 Debra J. Rose,1 Valerie Burland,1 Voula Kodoyianni,1,2 David C. Schwartz,1,2 and Frederick R. Blattner1*

Laboratory of Genetics,1 Genome Center of Wisconsin, University of Wisconsin, Madison, Wisconsin 537062

Received 26 August 2002/ Accepted 7 January 2003

We present the 4.8-Mb complete genome sequence of Salmonella enterica serovar Typhi strain Ty2, a human-specific pathogen causing typhoid fever. A comparison with the genome sequence of recently isolated S. enterica serovar Typhi strain CT18 showed that 29 of the 4,646 predicted genes in Ty2 are unique to this strain, while 84 genes are unique to CT18. Both genomes contain more than 200 pseudogenes; 9 of these genes in CT18 are intact in Ty2, while 11 intact CT18 genes are pseudogenes in Ty2. A half-genome interreplichore inversion in Ty2 relative to CT18 was confirmed. The two strains exhibit differences in prophages, insertion sequences, and island structures. While CT18 carries two plasmids, one conferring multiple drug resistance, Ty2 has no plasmids and is sensitive to antibiotics.

* Corresponding author. Mailing address: Laboratory of Genetics, University of Wisconsin—Madison, 445 Henry Mall, Madison, WI 53706. Phone: (608) 262-2534. Fax: (608) 263-7459. E-mail: fred{at}genome.wisc.edu.

{dagger} Paper 3604 from the Laboratory of Genetics, University of Wisconsin.

{ddagger} Present address: Department of Ecology and Evolution, State University of New York, Stony Brook, NY 11794.

Journal of Bacteriology, April 2003, p. 2330-2337, Vol. 185, No. 7
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.7.2330-2337.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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