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Journal of Bacteriology, April 2003, p. 2362-2368, Vol. 185, No. 7
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.7.2362-2368.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genome Organization and Molecular Analysis of the Temperate Bacteriophage MM1 of Streptococcus pneumoniae

Virginia Obregón, José L. García, Ernesto García, Rubens López,* and Pedro García

Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas, CSIC, 28006 Madrid, Spain

Received 16 October 2002/ Accepted 7 January 2003

The genome of MM1 (40,248 bp), a temperate bacteriophage from the Spain23F-1 multiresistant epidemic clone of Streptococcus pneumoniae, is organized in 53 open reading frames (ORFs) and in at least five functional clusters. Bioinformatic and N-terminal amino acid sequence analyses enabled the assignment of possible functions to 26 ORFs. Analyses comparing the MM1 genome with those of other bacteriophages revealed similarities, mainly with genomes of phages infecting gram-positive bacteria, which suggest recent exchange of genes between species colonizing the same habitat.

* Corresponding author. Mailing address: Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas, CSIC, Velázquez 144, 28006 Madrid, Spain. Phone: (34) 91 561 1800. Fax: (34) 91 562 7518. E-mail: ruben{at}cib.csic.es.

Journal of Bacteriology, April 2003, p. 2362-2368, Vol. 185, No. 7
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.7.2362-2368.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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