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Journal of Bacteriology, January 2004, p. 244-247, Vol. 186, No. 1
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.1.244-247.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Necessity of Meningococcal {gamma}-Glutamyl Aminopeptidase for Neisseria meningitidis Growth in Rat Cerebrospinal Fluid (CSF) and CSF-Like Medium

Hideyuki Takahashi, Kenji Hirose, and Haruo Watanabe*

Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan

Received 25 September 2003/ Accepted 30 September 2003

The growth of a {gamma}-glutamyl aminopeptidase (GGT)-deficient Neisseria meningitidis strain was much slower than that of the parent strain in rat cerebrospinal fluid (CSF) and in a synthetic CSF-mimicking medium, and the growth failure was suppressed by the addition of cysteine. These results suggested that, in the environment of cysteine shortage, meningococcal GGT provided an advantage for meningococcal multiplication by supplying cysteine from environmental {gamma}-glutamyl-cysteinyl peptides.

* Corresponding author. Mailing address: Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan. Phone: 81-3-5285-1111. Fax: 81-3-5285-1171. E-mail: haruwata{at}nih.go.jp.

Journal of Bacteriology, January 2004, p. 244-247, Vol. 186, No. 1
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.1.244-247.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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