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Journal of Bacteriology, January 2004, p. 248-252, Vol. 186, No. 1
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.1.248-252.2004

Transcriptome Analysis of the Response of Pseudomonas aeruginosa to Hydrogen Peroxide

Marco Palma,1 Darrow DeLuca,1 Stefan Worgall,2 and Luis E. N. Quadri1*

Department of Microbiology and Immunology,1 Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York 100212

Received 14 July 2003/ Accepted 29 September 2003

Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H2O2 and untreated controls. The data indicate that the early response of P. aeruginosa to H2O2 consists of an upregulation of protective mechanisms and a downregulation of primary metabolism.

* Corresponding author. Mailing address: Medical College of Cornell University, Microbiology and Immunology, 1300 York Ave., Box 62, W-706, New York, NY 10021. Phone: (212) 746-4497. Fax: (212) 746-4028. E-mail: leq2001{at}med.cornell.edu.

Journal of Bacteriology, January 2004, p. 248-252, Vol. 186, No. 1
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.1.248-252.2004




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