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Journal of Bacteriology, January 2004, p. 248-252, Vol. 186, No. 1
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.1.248-252.2004

Transcriptome Analysis of the Response of Pseudomonas aeruginosa to Hydrogen Peroxide

Department of Microbiology and Immunology,¹ Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York 10021²

Received 14 July 2003/ Accepted 29 September 2003

Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H₂O₂ and untreated controls. The data indicate that the early response of P. aeruginosa to H₂O₂ consists of an upregulation of protective mechanisms and a downregulation of primary metabolism.

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