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Drastic Differences in Crh and HPr Synthesis Levels Reflect Their Different Impacts on Catabolite Repression in Bacillus subtilis

Laboratoire de Chimie Bactérienne, UPR 9043, Institut de Biologie Structurale et Microbiologie-CNRS, 13009 Marseille, France

Received 19 December 2003/ Accepted 21 January 2004

In Bacillus subtilis, carbon catabolite repression (CCR) of catabolic genes is mediated by ATP-dependent phosphorylation of HPr and Crh. Here we show that the different efficiencies with which these two proteins contribute to CCR may be due to the drastic differences in their synthesis rates under conditions that cause CCR.

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