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Journal of Bacteriology, May 2004, p. 3274-3277, Vol. 186, No. 10
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.10.3274-3277.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

–1 Frameshifting at a CGA AAG Hexanucleotide Site Is Required for Transposition of Insertion Sequence IS1222

Nina Mejlhede,1,2,{dagger} Patricia Licznar,1 Marie-Françoise Prère,1 Norma M. Wills,2 Raymond F. Gesteland,2 John F. Atkins,2 and Olivier Fayet1*

Laboratoire de Microbiologie et Génétique Moléculaire, UMR5100 Centre National de la Recherche Scientifique et Université Paul Sabatier, Toulouse 31062-cedex, France,1 Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112-53302

Received 29 October 2003/ Accepted 2 February 2004

The discovery of programmed –1 frameshifting at the hexanucleotide shift site CGA_AAG, in addition to the classical X_XXY_YYZ heptanucleotide shift sequences, prompted a search for instances among eubacterial insertion sequence elements. IS1222 has a CGA_AAG shift site. A genetic analysis revealed that frameshifting at this site is required for transposition.

* Corresponding author. Mailing address: Laboratoire de Microbiologie et Génétique Moléculaire, UMR5100 Centre National de la Recherche Scientifique et Université Paul Sabatier, 118 route de Narbonne, Toulouse 31062-cedex, France. Phone: 33 5 61 33 58 75. Fax: 33 5 61 33 58 86. E-mail: Olivier.Fayet{at}ibcg.biotoul.fr.

{dagger} Present address: Riso National Laboratory, Plant Research Department, DK-4000 Roskilde, Denmark.

Journal of Bacteriology, May 2004, p. 3274-3277, Vol. 186, No. 10
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.10.3274-3277.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mazauric, M.-H., Licznar, P., Prere, M.-F., Canal, I., Fayet, O. (2008). Apical Loop-Internal Loop RNA Pseudoknots: A NEW TYPE OF STIMULATOR OF-1 TRANSLATIONAL FRAMESHIFTING IN BACTERIA. J. Biol. Chem. 283: 20421-20432 [Abstract] [Full Text]  


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