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Journal of Bacteriology, June 2004, p. 3656-3659, Vol. 186, No. 11
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.11.3656-3659.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Butyrivibrio fibrisolvens tet(W) Gene Is Carried on the Novel Conjugative Transposon TnB1230, Which Contains Duplicated Nitroreductase Coding Sequences

Claire M. Melville,{dagger} Romain Brunel, Harry J. Flint, and Karen P. Scott*

Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, United Kingdom

Received 11 November 2003/ Accepted 13 February 2004

The Butyrivibrio fibrisolvens tet(W) gene is located on the conjugative transposon TnB1230. TnB1230 encodes transfer proteins with 48 to 67% identity to some of those encoded by Tn1549. tet(W) is flanked by directly repeated sequences with significant homology to oxygen-insensitive nitroreductases. The 340 nucleotides upstream of tet(W) are strongly conserved and are required for tetracycline resistance.

* Corresponding author. Mailing address: Rowett Research Institute, Greenburn Rd., Bucksburn, Aberdeen AB21 9SB, United Kingdom. Phone: 44 (0) 1224 712751. Fax: 44 (0) 1224 716687. E-mail: K.Scott{at}rowett.ac.uk.

{dagger} Present address: Moredun Research Institute, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, United Kingdom.

Journal of Bacteriology, June 2004, p. 3656-3659, Vol. 186, No. 11
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.11.3656-3659.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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