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Journal of Bacteriology, July 2004, p. 4824-4828, Vol. 186, No. 14
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.14.4824-4828.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Whole-Genome Expression Profiling of Thermotoga maritima in Response to Growth on Sugars in a Chemostat

Tu N. Nguyen,1 Arvin D. Ejaz,2 Mark A. Brancieri,1,{dagger} Amy M. Mikula,2 Karen E. Nelson,2 Steven R. Gill,2 and Kenneth M. Noll1*

Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut,1 The Institute for Genomic Research, Rockville, Maryland2

Received 19 December 2003/ Accepted 14 April 2004

To provide data necessary to study catabolite-linked transcriptional networks in Thermotoga maritima, we used full-genome DNA microarray analysis of global transcriptional responses to growth on glucose, lactose, and maltose in a chemostat. A much larger number of genes changed expression in cells grown on lactose than on maltose, each relative to genes expressed in cells grown on glucose. Genes encoding putative oligopeptide transporters were often coregulated with adjacent glycosidase-encoding genes. Genes encoding enzymes catalyzing NADH oxidation were up-regulated on both lactose and maltose. Genes involved in iron and sulfur metabolism were differentially expressed in response to lactose. These data help define the sets of coregulated genes and suggest possible functions for their encoded products.

* Corresponding author. Mailing address: Department of Molecular and Cell Biology, University of Connecticut, U-3125, 91 N. Eagleville Rd., Storrs, CT 06269-3125. Phone: (860) 486-4688. Fax: (860) 486-4331. E-mail: noll{at}uconn.edu.

{dagger} Present address: Baxter Healthcare Corporation, Beltsville, Md.

Journal of Bacteriology, July 2004, p. 4824-4828, Vol. 186, No. 14
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.14.4824-4828.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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