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Journal of Bacteriology, August 2004, p. 5167-5171, Vol. 186, No. 15
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.15.5167-5171.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The ompU Paralogue vca1008 Is Required for Virulence of Vibrio cholerae

Tufts University Medical School, Tufts University, Boston, Massachusetts 02111,² Programa de Microbiología y Micología, Facultad de Medicina, Universidad de Chile, Santiago, Chile¹

Received 19 January 2004/ Accepted 5 May 2004

We made single and combined mutations in ompU, ompT, and the two putative porin genes vca1008 and vc0972. The fitness of the strains was tested in vitro and in the infant mouse model of intestinal infection. We also studied the transcriptional induction of vca1008 in vitro and during mouse infection. We show that vca1008 is induced during infection and is necessary and sufficient (in the absence of ompU, ompT, and vc0972) for infection.

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