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Journal of Bacteriology, August 2004, p. 5182-5185, Vol. 186, No. 15
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.15.5182-5185.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Evolution of the Helicobacter pylori Vacuolating Cytotoxin in a Human Stomach

Francisco Aviles-Jimenez,1 Darren P. Letley,1 Gerardo Gonzalez-Valencia,2 Nina Salama,3 Javier Torres,2 and John C. Atherton1*

Wolfson Digestive Diseases Centre and Institute of Infection, Immunity and Inflammation, University of Nottingham, University Hospital, Nottingham NG7 2UH, United Kingdom,1 Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico,2 Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington3

Received 5 March 2004/ Accepted 27 April 2004

We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity.

* Corresponding author. Mailing address: Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, United Kingdom. Phone: 44 115 9249924. Fax: 44 115 9422232. E-mail: john.atherton{at}nottingham.ac.uk.

Journal of Bacteriology, August 2004, p. 5182-5185, Vol. 186, No. 15
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.15.5182-5185.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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