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Journal of Bacteriology, August 2004, p. 5538-5542, Vol. 186, No. 16
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.16.5538-5542.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Polymorphic Mutation Frequencies in Escherichia coli: Emergence of Weak Mutators in Clinical Isolates

María-Rosario Baquero,1 Annika I. Nilsson,2,3 María del Carmen Turrientes,1 Dorthe Sandvang,4 Juan Carlos Galán,1 Jose Luís Martínez,5 Niels Frimodt-Møller,4 Fernando Baquero,1* and Dan I. Andersson2,3

Hospital Ramón y Cajal,1 National Center for Biotechnology, Madrid, Spain,5 Swedish Institute for Infectious Disease Control,2 Karolinska Institute, Solna, Sweden,3 Statens Serum Institut, Copenhagen, Denmark4

Received 24 February 2004/ Accepted 18 May 2004

Polymorphisms in the rifampin resistance mutation frequency (f) were studied in 696 Escherichia coli strains from Spain, Sweden, and Denmark. Of the 696 strains, 23% were weakly hypermutable (4 x 10–8 ≤ f < 4 x 10–7), and 0.7% were strongly hypermutable (f ≥ 4 x 10–7). Weak mutators were apparently more frequent in southern Europe and in blood isolates (38%) than in urinary tract isolates (25%) and feces of healthy volunteers (11%).

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Ramón y Cajal, Ctra. de Colmenar, Km 9.1, 28034 Madrid, Spain. Phone: 34-91-3368330. Fax: 34-91-3368809. E-mail: fbaquero.hrc{at}salud.madrid.org.

Journal of Bacteriology, August 2004, p. 5538-5542, Vol. 186, No. 16
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.16.5538-5542.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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