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Journal of Bacteriology, September 2004, p. 5956-5960, Vol. 186, No. 17
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.17.5956-5960.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

FlhF, the Third Signal Recognition Particle-GTPase of Bacillus subtilis, Is Dispensable for Protein Secretion

Geeske Zanen,1 Haike Antelmann,2 Helga Westers,1,{dagger} Michael Hecker,2 Jan Maarten van Dijl,1* and Wim J. Quax1

Department of Pharmaceutical Biology, University of Groningen, Groningen, The Netherlands,1 Institut für Mikrobiologie und Molekularbiologie, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany2

Received 11 March 2004/ Accepted 8 June 2004

Bacillus subtilis contains three proteins of the signal recognition particle-GTPase family known as Ffh, FtsY, and FlhF. Here we show that FlhF is dispensable for protein secretion, unlike Ffh and FtsY. Although flhF is located in the fla/che operon, B. subtilis 168 flhF mutant cells assemble flagella and are motile.

* Corresponding author. Present address: Department of Molecular Bacteriology, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands. Phone: 31-50-3633079. Fax: 31-50-3633528. E-mail: J.M.van.Dijl{at}med.rug.nl.

{dagger} Present address: Department of Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751 NN Haren, The Netherlands.

Journal of Bacteriology, September 2004, p. 5956-5960, Vol. 186, No. 17
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.17.5956-5960.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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