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Journal of Bacteriology, September 2004, p. 5968-5971, Vol. 186, No. 17
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.17.5968-5971.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Overexpression of gnsA, a Multicopy Suppressor of the secG Null Mutation, Increases Acidic Phospholipid Contents by Inhibiting Phosphatidylethanolamine Synthesis at Low Temperatures

Rie Sugai, Hisayo Shimizu, Ken-ichi Nishiyama, and Hajime Tokuda*

Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan

Received 22 April 2004/ Accepted 3 June 2004

GnsA overproduction was previously found to suppress both the secG null mutation and the fabA6 mutation in Escherichia coli by increasing the unsaturated fatty acid contents. We report here that it also increased the acidic phospholipid contents at 20°C but not at 37°C. GnsA overproduction at 20°C specifically inhibited phosphatidylethanolamine synthesis and therefore caused the increase in the proportion of acidic phospholipids.

* Corresponding author. Mailing address: Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Phone: 81-3-5841-7830. Fax: 81-3-5841-8464. E-mail: htokuda{at}iam.u-tokyo.ac.jp.

Journal of Bacteriology, September 2004, p. 5968-5971, Vol. 186, No. 17
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.17.5968-5971.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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