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Journal of Bacteriology, September 2004, p. 6316-6319, Vol. 186, No. 18
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.18.6316-6319.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Bacterial Thymidylate Synthase with Intein, Group II Intron, and Distinctive ThyX Motifs

Xiang-Qin Liu* and Jing Yang

Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada

Received 8 April 2004/ Accepted 25 May 2004

The ThyX class of thymidylate synthases was previously characterized by a common ThyX motif, RHRX7S. We report bacterial ThyX sequences having distinctive ThyX motifs, suggesting a more general ThyX motif, R/THRX7-8S. One ThyX sequence has an intein in its ThyX motif that was shown to do protein splicing and a group II intron in its gene, suggesting a hot spot for these self-splicing mobile elements.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada. Phone: (902) 494-1208. Fax: (902) 494-1355. E-mail: pxqliu{at}dal.ca.

Journal of Bacteriology, September 2004, p. 6316-6319, Vol. 186, No. 18
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.18.6316-6319.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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