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Journal of Bacteriology, January 2004, p. 575-579, Vol. 186, No. 2
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.2.575-579.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa That Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A

Departments of Pediatrics,¹ Medicine,² Microbiology,³ Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195⁴

Received 27 June 2003/ Accepted 19 October 2003

Spontaneous polymyxin-resistant mutants of Pseudomonas aeruginosa were isolated. The mutations responsible for this phenotype were mapped to a two-component signal transduction system similar to PmrAB of Salmonella enterica serovar Typhimurium. Lipid A of these mutants contained aminoarabinose, an inducible modification that is associated with polymyxin resistance. Thus, P. aeruginosa possesses a mechanism that induces resistance to cationic antimicrobial peptides in response to environmental conditions.

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