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Journal of Bacteriology, October 2004, p. 7019-7022, Vol. 186, No. 20
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.20.7019-7022.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Treponema pallidum Fibronectin-Binding Proteins

Caroline E. Cameron,* Elizabeth L. Brown, Janelle M. Y. Kuroiwa, Lynn M. Schnapp, and Nathan L. Brouwer

Department of Medicine, University of Washington, Seattle, Washington

Received 24 March 2004/ Accepted 19 July 2004

Putative adhesins were predicted by computer analysis of the Treponema pallidum genome. Two treponemal proteins, Tp0155 and Tp0483, demonstrated specific attachment to fibronectin, blocked bacterial adherence to fibronectin-coated slides, and supported attachment of fibronectin-producing mammalian cells. These results suggest Tp0155 and Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions.

* Corresponding author. Mailing address: Box 357185, Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, WA 98195. Phone: (206) 616-9046. Fax: (206) 685-8681. E-mail: caroc{at}u.washington.edu.

Journal of Bacteriology, October 2004, p. 7019-7022, Vol. 186, No. 20
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.20.7019-7022.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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