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Journal of Bacteriology, November 2004, p. 7450-7455, Vol. 186, No. 21
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.21.7450-7455.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Increased Stability of bmr3 mRNA Results in a Multidrug-Resistant Phenotype in Bacillus subtilis

Reiko Ohki* and Kozue Tateno

Department of Molecular Biology, School of Health Sciences, Kyorin University, Hachioji, Tokyo, Japan

Received 22 June 2004/ Accepted 4 August 2004

A spontaneous mutant isolated in the presence of a high concentration of puromycin acquired a multidrug-resistant phenotype. Expression of the bmr3 gene was dramatically increased. A base substitution, T to A at the +4 position, detected in the mutant resulted in the stabilization of bmr3 mRNA.

* Corresponding author. Mailing address: Department of Molecular Biology, School of Health Sciences, Kyorin University, 476 Miyashita, Hachioji, Tokyo 192-0005, Japan. Phone: 81 426 91 0011. Fax: 81 426 91 1094. E-mail: ohkir{at}kyorin-u.ac.jp.

Journal of Bacteriology, November 2004, p. 7450-7455, Vol. 186, No. 21
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.21.7450-7455.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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