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Journal of Bacteriology, November 2004, p. 7811-7814, Vol. 186, No. 22
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.22.7811-7814.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Mutation of a Single Lytic Transglycosylase Causes Aberrant Septation and Inhibits Cell Separation of Neisseria gonorrhoeae

Department of Medical Microbiology and Immunology, University of Wisconsin— Madison Medical School, Madison, Wisconsin

Received 17 June 2004/ Accepted 12 August 2004

The function of lytic peptidoglycan transglycosylases is poorly understood. Single lytic transglycosylase mutants of Escherichia coli have no growth phenotype. By contrast, mutation of Neisseria gonorrhoeae ltgC inhibited cell separation without affecting peptidoglycan monomer production. Thus, LtgC has a dedicated function in gonococcal cell division.

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