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Cold Sensitivity of Thermophilic and Mesophilic RNA Polymerases

Institute of Molecular Genetics, Moscow, Russia,¹ Public Health Research Institute, Newark, New Jersey²

Received 19 May 2004/ Accepted 11 August 2004

RNA polymerase from mesophilic Deinococcus radiodurans displays the same cold sensitivity of promoter opening as RNA polymerase from the closely related thermophilic Thermus aquaticus. This suggests that, contrary to the accepted view, cold sensitivity of promoter opening by thermophilic RNA polymerases may not be a consequence of their thermostability.

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