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Journal of Bacteriology, November 2004, p. 7818-7820, Vol. 186, No. 22
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.22.7818-7820.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Cold Sensitivity of Thermophilic and Mesophilic RNA Polymerases

A. Kulbachinskiy,1,2* I. Bass,1 E. Bogdanova,1 A. Goldfarb,2 and V. Nikiforov1,2

Institute of Molecular Genetics, Moscow, Russia,1 Public Health Research Institute, Newark, New Jersey2

Received 19 May 2004/ Accepted 11 August 2004

RNA polymerase from mesophilic Deinococcus radiodurans displays the same cold sensitivity of promoter opening as RNA polymerase from the closely related thermophilic Thermus aquaticus. This suggests that, contrary to the accepted view, cold sensitivity of promoter opening by thermophilic RNA polymerases may not be a consequence of their thermostability.

* Corresponding author. Mailing address: Laboratory of Molecular Genetics of Microorganisms, Institute of Molecular Genetics, Kurchatov Sq. 2, Moscow 123182, Russia. Phone: 7 (095) 1960015. Fax: 7 (095) 1960015. E-mail: akulb{at}img.ras.ru.

Journal of Bacteriology, November 2004, p. 7818-7820, Vol. 186, No. 22
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.22.7818-7820.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Barinova, N., Kuznedelov, K., Severinov, K., Kulbachinskiy, A. (2008). Structural Modules of RNA Polymerase Required for Transcription from Promoters Containing Downstream Basal Promoter Element GGGA. J. Biol. Chem. 283: 22482-22489 [Abstract] [Full Text]  
  • Barinova, N., Zhilina, E., Bass, I., Nikiforov, V., Kulbachinskiy, A. (2008). Lineage-Specific Amino Acid Substitutions in Region 2 of the RNA Polymerase {sigma} Subunit Affect the Temperature of Promoter Opening. J. Bacteriol. 190: 3088-3092 [Abstract] [Full Text]  
  • Sevostyanova, A., Feklistov, A., Barinova, N., Heyduk, E., Bass, I., Klimasauskas, S., Heyduk, T., Kulbachinskiy, A. (2007). Specific Recognition of the -10 Promoter Element by the Free RNA Polymerase {sigma} Subunit. J. Biol. Chem. 282: 22033-22039 [Abstract] [Full Text]  
  • Schroeder, L. A., deHaseth, P. L. (2005). Mechanistic Differences in Promoter DNA Melting by Thermus aquaticus and Escherichia coli RNA Polymerases. J. Biol. Chem. 280: 17422-17429 [Abstract] [Full Text]  


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