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Journal of Bacteriology, December 2004, p. 8524-8528, Vol. 186, No. 24
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.24.8524-8528.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The F-ATPase Operon Promoter of Streptococcus mutans Is Transcriptionally Regulated in Response to External pH

Wendi L. Kuhnert,1,{dagger} Guolu Zheng,2 Roberta C. Faustoferri,2 and Robert G. Quivey Jr.1,2*

Center for Oral Biology, Aab Institute for Biomedical Sciences,2 Department of Microbiology and Immunology, University of Rochester, Rochester, New York1

Received 25 May 2004/ Accepted 15 September 2004

Streptococcus mutans F-ATPase, the major component of the acid-adaptive response of the organism, is transcriptionally upregulated at low pH. Fusions of the F-ATPase promoter to chloramphenicol acetyltransferase indicated that pH-dependent expression is still observed with a short promoter that contains a domain conserved between streptococcal ATPase operons.

* Corresponding author. Mailing address: Center for Oral Biology, Box 611, 601 Elmwood Ave., Rochester, NY 14642. Phone: (585) 275-0382. Fax: (585) 276-0190. E-mail: Robert_Quivey{at}urmc.rochester.edu.

{dagger} Present address: Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.

Journal of Bacteriology, December 2004, p. 8524-8528, Vol. 186, No. 24
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.24.8524-8528.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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