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Journal of Bacteriology, December 2004, p. 8537-8541, Vol. 186, No. 24
0021-9193/04/$08.00+0 DOI: 10.1128/JB.186.24.8537-8541.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
Département de Pathologie et Microbiologie, Université de Montréal, St-Hyacinthe,1 Department of Biology, Concordia University, Montréal, Quebec, Canada,3 Laboratoire de Microbiologie, Institut National de la Recherche Agronomique, St-Genès-Champanelle, France2
Received 8 January 2004/ Accepted 6 September 2004
The foo operon encodes F1651 fimbriae that belong to the P-regulatory family and are synthesized by septicemic Escherichia coli. Using an Lrp-deficient host and the lrp gene cloned under the arabinose pBAD promoter, we demonstrated that foo was transcribed proportionally to the amount of Lrp synthesized. L-Leucine and L-alanine decreased drastically the steady-state transcription of foo and modified phase variation, independently of the presence of FooI. Specific mutations in the C-terminal region of Lrp reduced or abolished the repressive effect of these amino acids, indicating that they modulate F1651 by affecting Lrp.
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