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Journal of Bacteriology, February 2004, p. 1197-1199, Vol. 186, No. 4
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.4.1197-1199.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

PriA Is Essential for Viability of the Escherichia coli Topoisomerase IV parE10(Ts) Mutant

Gianfranco Grompone,{dagger} Vladimir Bidnenko, S. Dusko Ehrlich, and Bénédicte Michel*

Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas, France

Received 15 September 2003/ Accepted 10 November 2003

The parE10(Ts) mutation, which renders Escherichia coli thermosensitive for growth by inactivation of the essential E. coli topoisomerase topo IV, is lethal at all temperatures when PriA, the main replication restart protein, is absent. This lethality is suppressed by the activation of a PriA-independent replication restart pathway (dnaC809 mutation). This result suggests that topo IV acts prior to full-chromosome replication completion.

* Corresponding author. Mailing address: Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, Jouy en Josas Cedex 78352, France. Phone: 33 1 34 65 25 14. Fax: 33 1 34 65 25 21. E-mail: Benedicte.Michel{at}jouy.inra.fr.

{dagger} Present address: Institut Pasteur, 75015 Paris, France.

Journal of Bacteriology, February 2004, p. 1197-1199, Vol. 186, No. 4
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.4.1197-1199.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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