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Journal of Bacteriology, February 2004, p. 1215-1219, Vol. 186, No. 4
0021-9193/04/$08.00+0 DOI: 10.1128/JB.186.4.1215-1219.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
InvB Is Required for Type III-Dependent Secretion of SopA in Salmonella enterica Serovar Typhimurium
Kristin Ehrbar, Siegfried Hapfelmeier, Bärbel Stecher, and Wolf-Dietrich Hardt*
Institute of Microbiology, ETH Zürich, 8092 Zürich, Switzerland
Received 2 September 2003/
Accepted 11 November 2003
The Salmonella effector protein SopA is translocated into host cells via the SPI-1 type III secretion system (TTSS) and contributes to enteric disease. We found that the chaperone InvB binds to SopA and slightly stabilizes it in the bacterial cytosol and that it is required for its transport via the SPI-1 TTSS.
* Corresponding author. Mailing address: Institute of Microbiology, ETH Zürich, Schmelzbergstrasse 7, 8092 Zürich, Switzerland. Fax: 41-1-632-1129. Phone: 41-1-632-5143. E-mail: hardt{at}micro.biol.ethz.ch.
Journal of Bacteriology, February 2004, p. 1215-1219, Vol. 186, No. 4
0021-9193/04/$08.00+0 DOI: 10.1128/JB.186.4.1215-1219.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
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Copyright © 2004 by the American Society for Microbiology. All rights reserved.