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The PaaX Repressor, a Link between Penicillin G Acylase and the Phenylacetyl-Coenzyme A Catabolon of Escherichia coli W

Department of Molecular Microbiology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

Received 21 October 2003/ Accepted 30 December 2003

The pac gene, encoding the penicillin G acylase from Escherichia coli W, is regulated by the PaaX repressor of the phenylacetate catabolic pathway. pac expression depends on the synthesis of phenylacetyl-coenzyme A. PaaX and the cyclic AMP receptor protein (CRP) bind in vitro to the Ppac promoter region. A palindromic sequence proposed as the PaaX operator is located upstream of the –35 box overlapping a CRP binding site, an unusual position that suggests a novel regulatory mechanism.

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