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Journal of Bacteriology, April 2004, p. 2492-2494, Vol. 186, No. 8
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.8.2492-2494.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Core Escherichia coli Signal Recognition Particle Receptor Contains Only the N and G Domains of FtsY

Asa Eitan and Eitan Bibi*

Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel

Received 12 November 2003/ Accepted 6 January 2004

Previous studies have proposed that the N-terminal A domain (~200 amino acid residues) of the Escherichia coli signal recognition particle (SRP) receptor, FtsY, is required for membrane targeting. In contrast to this suggestion, we show that A domain-truncated versions of FtsY, harboring only domains N and G, are functional. Therefore, we propose that N and G domains constitute the core SRP receptor.

* Corresponding author. Mailing address: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel. Phone: 972-8-9343464. Fax: 972-8-9344118. E-mail: e.bibi{at}weizmann.ac.il.

Journal of Bacteriology, April 2004, p. 2492-2494, Vol. 186, No. 8
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.8.2492-2494.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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