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Journal of Bacteriology, April 2004, p. 2504-2507, Vol. 186, No. 8
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.8.2504-2507.2004

Interplay between Plasmid Partition and Postsegregational Killing Systems

Therese Brendler, Lucretia Reaves, and Stuart Austin*

Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, Center for Cancer Research, NCI—Frederick, Frederick, Maryland 21702-1201

Received 13 November 2003/ Accepted 30 December 2003

Active partition systems and postsegregational killing (PSK) systems are present together in naturally occurring low-copy-number plasmids. Theory suggests that PSK may act as the ultimate determinant of plasmid retention, whereas the partition system may minimize the growth penalty to the host, resulting in a near-ideal symbiosis when the systems combine. Here, we prove the validity of this principle for a specific case involving the P1par system and the mvp PSK system.

* Corresponding author. Mailing address: NCI—Frederick, GRCBL, P.O. Box B, Frederick, MD 21702-1201. Phone: (301) 846-1266. Fax: (301) 846-6988. E-mail: austin{at}ncifcrf.gov.

Journal of Bacteriology, April 2004, p. 2504-2507, Vol. 186, No. 8
0021-9193/04/$08.00+0     DOI: 10.1128/JB.186.8.2504-2507.2004




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