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Journal of Bacteriology, May 2005, p. 3593-3598, Vol. 187, No. 10
0021-9193/05/$08.00+0     doi:10.1128/JB.187.10.3593-3598.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

An Adenylyl Cyclase, CyaB, Acts as an Osmosensor in Myxococcus xanthus

Department of Life Sciences, Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa, Japan 761-0795

Received 1 November 2004/ Accepted 4 February 2005

We have previously reported that a receptor-type adenylyl cyclase (CyaA) of Myxococcus xanthus undergoes an osmosensor mainly during spore germination (Y. Kimura et al., J. Bacteriol. 184:3578-3585, 2002). In the present study, we cloned another receptor-type adenylyl cyclase gene (cyaB) and characterized the function of the cyaB-encoded protein. Disruption of cyaB generates a mutant that showed growth retardation at high ionic (NaCl) or high nonionic (sucrose) osmolarity. When vegetative cells were stimulated with 0.15 M NaCl, the increases in intracellular cyclic AMP levels of cyaB mutant cells were lower than those of wild-type cells. Under nonionic osmostress, the cyaB mutant exhibited reduced spore germination; however, the germination rate of the cyaB mutant was significantly higher than that of the cyaA mutant.

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