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Journal of Bacteriology, June 2005, p. 3878-3883, Vol. 187, No. 11
0021-9193/05/$08.00+0     doi:10.1128/JB.187.11.3878-3883.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Two Additional Components of the Accessory Sec System Mediating Export of the Streptococcus gordonii Platelet-Binding Protein GspB

Daisuke Takamatsu, Barbara A. Bensing, and Paul M. Sullam*

Department of Medicine, Veterans Affairs Medical Center, and the University of California, San Francisco, California

Received 7 December 2004/ Accepted 16 February 2005

The gspB-secY2A2 locus of Streptococcus gordonii strain M99 encodes the platelet-binding glycoprotein GspB, along with proteins that mediate its glycosylation and export. We have identified two additional components of the accessory Sec system (Asp4 and Asp5) encoded just downstream of gtfB in the gspB-secY2A2 locus. These proteins are required for GspB export and for normal levels of platelet binding by M99. Asp4 and Asp5 may be functional homologues of SecE and SecG, respectively.

* Corresponding author. Mailing address: Division of Infectious Diseases, VA Medical Center (111W), 4150 Clement Street, San Francisco, CA 94121. Phone: (415) 221-4810, ext. 2550. Fax: (415) 750-0502. E-mail: sullam{at}itsa.ucsf.edu.

Journal of Bacteriology, June 2005, p. 3878-3883, Vol. 187, No. 11
0021-9193/05/$08.00+0     doi:10.1128/JB.187.11.3878-3883.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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