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The eefABC Multidrug Efflux Pump Operon Is Repressed by H-NS in Enterobacter aerogenes

Muriel Masi,¹ Jean-Marie Pagès,^1* Claude Villard,² and Elizabeth Pradel^1,

Enveloppe bactérienne, Perméabilité et Antibiotiques, EA2197, IFR 48, Faculté de Médecine, Marseille, France ,¹ Plate-forme Protéomique, Faculté de Pharmacie, Marseille, France²

Received 15 December 2004/ Accepted 18 February 2005

The Enterobacter aerogenes eefABC locus, which encodes a tripartite efflux pump, was cloned by complementation of an Escherichia coli tolC mutant. E. aerogenes acrA expressing EefABC became less susceptible to a wide range of antibiotics. Data from eef::lacZ fusions showed that eefABC was not transcribed in the various laboratory conditions tested. However, increased transcription from Peef was observed in an E. coli hns mutant. In addition, EefA was detected in E. aerogenes expressing a dominant negative E. coli hns allele.

Present address: CIML, Inserm U631, case 906, 13288 Marseille cedex 09, France.

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