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Journal of Bacteriology, June 2005, p. 3898-3902, Vol. 187, No. 11
0021-9193/05/$08.00+0     doi:10.1128/JB.187.11.3898-3902.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Quorum Sensing Negatively Controls Type III Secretion Regulon Expression in Pseudomonas aeruginosa PAO1

Laboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS-IBSM-UPR9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France,¹ Centro de Pesquisa em Medicina Tropical, BP 87, Porto Velho, 78910-210 Rondônia, Brazil²

Received 27 November 2004/ Accepted 2 March 2005

A systematic analysis of the type III secretion (T3S) genes of Pseudomonas aeruginosa strain PAO1 revealed that they are under quorum-sensing control. This observation was supported by the down-regulation of the T3S regulon in the presence of RhlR-C₄HSL and the corresponding advanced secretion of ExoS in a rhlI mutant.

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