This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Svensson, K.
Right arrow Articles by Johansson, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Svensson, K.
Right arrow Articles by Johansson, A.

 Previous Article

Journal of Bacteriology, June 2005, p. 3903-3908, Vol. 187, No. 11
0021-9193/05/$08.00+0     doi:10.1128/JB.187.11.3903-3908.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Evolution of Subspecies of Francisella tularensis{dagger}

Kerstin Svensson,1 Pär Larsson,1,2 Daniel Johansson,1 Mona Byström,1 Mats Forsman,1 and Anders Johansson1,3*

Department of NBC-Analysis, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden,1 Department of Clinical Microbiology, Bacteriology,2 Department of Clinical Microbiology, Infectious Diseases, Umeå University, SE-901 85 Umeå, Sweden3

Received 26 November 2004/ Accepted 23 February 2005

Analysis of unidirectional genomic deletion events and single nucleotide variations suggested that the four subspecies of Francisella tularensis have evolved by vertical descent. The analysis indicated an evolutionary scenario where the highly virulent F. tularensis subsp. tularensis (type A) appeared before the less virulent F. tularensis subsp. holarctica (type B). Compared to their virulent progenitors, attenuated strains of F. tularensis exhibited specific unidirectional gene losses.

* Corresponding author. Mailing address: NBC-Analysis, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden. Phone: 46 90 10 66 16. Fax: 46 90 133006. E-mail: anders.johansson{at}infdis.umu.se.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, June 2005, p. 3903-3908, Vol. 187, No. 11
0021-9193/05/$08.00+0     doi:10.1128/JB.187.11.3903-3908.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lindgren, H., Honn, M., Golovlev, I., Kadzhaev, K., Conlan, W., Sjostedt, A. (2009). The 58-Kilodalton Major Virulence Factor of Francisella tularensis Is Required for Efficient Utilization of Iron. Infect. Immun. 77: 4429-4436 [Abstract] [Full Text]  
  • Salomonsson, E., Kuoppa, K., Forslund, A.-L., Zingmark, C., Golovliov, I., Sjostedt, A., Noppa, L., Forsberg, A. (2009). Reintroduction of Two Deleted Virulence Loci Restores Full Virulence to the Live Vaccine Strain of Francisella tularensis. Infect. Immun. 77: 3424-3431 [Abstract] [Full Text]  
  • Salomonsson, E., Forsberg, A., Roos, N., Holz, C., Maier, B., Koomey, M., Winther-Larsen, H. C. (2009). Functional analyses of pilin-like proteins from Francisella tularensis: complementation of type IV pilus phenotypes in Neisseria gonorrhoeae. Microbiology 155: 2546-2559 [Abstract] [Full Text]  
  • Vogler, A. J., Birdsell, D., Price, L. B., Bowers, J. R., Beckstrom-Sternberg, S. M., Auerbach, R. K., Beckstrom-Sternberg, J. S., Johansson, A., Clare, A., Buchhagen, J. L., Petersen, J. M., Pearson, T., Vaissaire, J., Dempsey, M. P., Foxall, P., Engelthaler, D. M., Wagner, D. M., Keim, P. (2009). Phylogeography of Francisella tularensis: Global Expansion of a Highly Fit Clone. J. Bacteriol. 191: 2474-2484 [Abstract] [Full Text]  
  • Gallagher, L. A., McKevitt, M., Ramage, E. R., Manoil, C. (2008). Genetic Dissection of the Francisella novicida Restriction Barrier. J. Bacteriol. 190: 7830-7837 [Abstract] [Full Text]  
  • La Scola, B., Elkarkouri, K., Li, W., Wahab, T., Fournous, G., Rolain, J.-M., Biswas, S., Drancourt, M., Robert, C., Audic, S., Lofdahl, S., Raoult, D. (2008). Rapid comparative genomic analysis for clinical microbiology: The Francisella tularensis paradigm. Genome Res 18: 742-750 [Abstract] [Full Text]  
  • Molins-Schneekloth, C. R., Belisle, J. T., Petersen, J. M. (2008). Genomic Markers for Differentiation of Francisella tularensis subsp. tularensis A.I and A.II Strains. Appl. Environ. Microbiol. 74: 336-341 [Abstract] [Full Text]  
  • Dempsey, M. P., Dobson, M., Zhang, C., Zhang, M., Lion, C., Gutierrez-Martin, C. B., Iwen, P. C., Fey, P. D., Olson, M. E., Niemeyer, D., Francesconi, S., Crawford, R., Stanley, M., Rhodes, J., Wagner, D. M., Vogler, A. J., Birdsell, D., Keim, P., Johansson, A., Hinrichs, S. H., Benson, A. K. (2007). Genomic Deletion Marking an Emerging Subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula. Appl. Environ. Microbiol. 73: 7465-7470 [Abstract] [Full Text]  
  • Guina, T., Radulovic, D., Bahrami, A. J., Bolton, D. L., Rohmer, L., Jones-Isaac, K. A., Chen, J., Gallagher, L. A., Gallis, B., Ryu, S., Taylor, G. K., Brittnacher, M. J., Manoil, C., Goodlett, D. R. (2007). MglA Regulates Francisella tularensis subsp. novicida (Francisella novicida) Response to Starvation and Oxidative Stress. J. Bacteriol. 189: 6580-6586 [Abstract] [Full Text]  
  • Thomas, R. M., Titball, R. W., Oyston, P. C. F., Griffin, K., Waters, E., Hitchen, P. G., Michell, S. L., Grice, I. D., Wilson, J. C., Prior, J. L. (2007). The Immunologically Distinct O Antigens from Francisella tularensis Subspecies tularensis and Francisella novicida Are both Virulence Determinants and Protective Antigens. Infect. Immun. 75: 371-378 [Abstract] [Full Text]  
  • Hajjar, A. M., Harvey, M. D., Shaffer, S. A., Goodlett, D. R., Sjostedt, A., Edebro, H., Forsman, M., Bystrom, M., Pelletier, M., Wilson, C. B., Miller, S. I., Skerrett, S. J., Ernst, R. K. (2006). Lack of In Vitro and In Vivo Recognition of Francisella tularensis Subspecies Lipopolysaccharide by Toll-Like Receptors. Infect. Immun. 74: 6730-6738 [Abstract] [Full Text]  
  • Rohmer, L., Brittnacher, M., Svensson, K., Buckley, D., Haugen, E., Zhou, Y., Chang, J., Levy, R., Hayden, H., Forsman, M., Olson, M., Johansson, A., Kaul, R., Miller, S. I. (2006). Potential Source of Francisella tularensis Live Vaccine Strain Attenuation Determined by Genome Comparison. Infect. Immun. 74: 6895-6906 [Abstract] [Full Text]  
  • Ben Nasr, A., Haithcoat, J., Masterson, J. E., Gunn, J. S., Eaves-Pyles, T., Klimpel, G. R. (2006). Critical role for serum opsonins and complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by human dendritic cells (DC): uptake of Francisella leads to activation of immature DC and intracellular survival of the bacteria. J. Leukoc. Biol. 80: 774-786 [Abstract] [Full Text]  
  • Dempsey, M. P., Nietfeldt, J., Ravel, J., Hinrichs, S., Crawford, R., Benson, A. K. (2006). Paired-End Sequence Mapping Detects Extensive Genomic Rearrangement and Translocation during Divergence of Francisella tularensis subsp. tularensis and Francisella tularensis subsp. holarctica Populations.. J. Bacteriol. 188: 5904-5914 [Abstract] [Full Text]  
  • Nubel, U., Reissbrodt, R., Weller, A., Grunow, R., Porsch-Ozcurumez, M., Tomaso, H., Hofer, E., Splettstoesser, W., Finke, E.-J., Tschape, H., Witte, W. (2006). Population Structure of Francisella tularensis.. J. Bacteriol. 188: 5319-5324 [Abstract] [Full Text]  
  • Twine, S., Bystrom, M., Chen, W., Forsman, M., Golovliov, I., Johansson, A., Kelly, J., Lindgren, H., Svensson, K., Zingmark, C., Conlan, W., Sjostedt, A. (2005). A Mutant of Francisella tularensis Strain SCHU S4 Lacking the Ability To Express a 58-Kilodalton Protein Is Attenuated for Virulence and Is an Effective Live Vaccine. Infect. Immun. 73: 8345-8352 [Abstract] [Full Text]  
  • Bystrom, M., Bocher, S., Magnusson, A., Prag, J., Johansson, A. (2005). Tularemia in Denmark: Identification of a Francisella tularensis subsp. holarctica Strain by Real-Time PCR and High-Resolution Typing by Multiple-Locus Variable-Number Tandem Repeat Analysis. J. Clin. Microbiol. 43: 5355-5358 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»