This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoffmann, K. M.
Right arrow Articles by Brennan, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoffmann, K. M.
Right arrow Articles by Brennan, R. G.

 Previous Article  |  Next Article 

Journal of Bacteriology, July 2005, p. 5008-5012, Vol. 187, No. 14
0021-9193/05/$08.00+0     doi:10.1128/JB.187.14.5008-5012.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of the Multiple Transferable Resistance Repressor, MtrR, from Neisseria gonorrhoeae

Katherine M. Hoffmann,1 Daniel Williams,2 William M. Shafer,2,3 and Richard G. Brennan1*

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, Oregon,1 Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia,2 Laboratories of Microbial Pathogenesis, VA Medical Research Service, Veterans Affairs Medical Center, Decatur, Georgia3

Received 17 February 2005/ Accepted 5 April 2005

MtrR represses expression of the Neisseria gonorrhoeae mtrCDE multidrug efflux transporter genes. MtrR displays salt-dependent DNA binding, a stoichiometry of two dimers per DNA site, and, for a protein that was expected to be essentially all helical, a high percentage of random coil and possibly ß-sheet structure.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239-3098. Phone: (503) 494-4427. Fax: (503) 494-8393. E-mail: brennanr{at}ohsu.edu.

Journal of Bacteriology, July 2005, p. 5008-5012, Vol. 187, No. 14
0021-9193/05/$08.00+0     doi:10.1128/JB.187.14.5008-5012.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Folster, J. P., Johnson, P. J. T., Jackson, L., Dhulipali, V., Dyer, D. W., Shafer, W. M. (2009). MtrR Modulates rpoH Expression and Levels of Antimicrobial Resistance in Neisseria gonorrhoeae. J. Bacteriol. 191: 287-297 [Abstract] [Full Text]  
  • Long, F., Rouquette-Loughlin, C., Shafer, W. M., Yu, E. W. (2008). Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob. Agents Chemother. 52: 3052-3060 [Abstract] [Full Text]  
  • Garvin, L. E., Bash, M. C., Keys, C., Warner, D. M., Ram, S., Shafer, W. M., Jerse, A. E. (2008). Phenotypic and Genotypic Analyses of Neisseria gonorrhoeae Isolates That Express Frequently Recovered PorB PIA Variable Region Types Suggest that Certain P1a Porin Sequences Confer a Selective Advantage for Urogenital Tract Infection. Infect. Immun. 76: 3700-3709 [Abstract] [Full Text]  
  • Folster, J. P., Dhulipala, V., Nicholas, R. A., Shafer, W. M. (2007). Differential Regulation of ponA and pilMNOPQ Expression by the MtrR Transcriptional Regulatory Protein in Neisseria gonorrhoeae. J. Bacteriol. 189: 4569-4577 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»