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Characterization of the Multiple Transferable Resistance Repressor, MtrR, from Neisseria gonorrhoeae

Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, Oregon,¹ Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia,² Laboratories of Microbial Pathogenesis, VA Medical Research Service, Veterans Affairs Medical Center, Decatur, Georgia³

Received 17 February 2005/ Accepted 5 April 2005

MtrR represses expression of the Neisseria gonorrhoeae mtrCDE multidrug efflux transporter genes. MtrR displays salt-dependent DNA binding, a stoichiometry of two dimers per DNA site, and, for a protein that was expected to be essentially all helical, a high percentage of random coil and possibly ß-sheet structure.

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