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Journal of Bacteriology, July 2005, p. 5044-5048, Vol. 187, No. 14
0021-9193/05/$08.00+0     doi:10.1128/JB.187.14.5044-5048.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mutator Effects in Escherichia coli Caused by the Expression of Specific Foreign Genes

Vanessa Gabrovsky, Mitsuko Lynn Yamamoto, and Jeffrey H. Miller*

Department of Microbiology, Immunology, and Molecular Genetics and The Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095

Received 24 January 2005/ Accepted 14 April 2005

Certain genes from Lactococcus lactis and Pseudomonas aeruginosa, including the nfxB gene, generate a mutator phenotype in Escherichia coli. The results of this study, together with those of a previous study, support conservation of regulatory sequences in E. coli and P. aeruginosa and suggest that some efflux pumps prevent mutagenicity by exporting mutagenic products of metabolism.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 405 Hilgard Ave., Los Angeles, CA 90095. Phone: (310) 825-8460. Fax: (310) 206-3088. E-mail: jhmiller{at}mbi.ucla.edu.

Journal of Bacteriology, July 2005, p. 5044-5048, Vol. 187, No. 14
0021-9193/05/$08.00+0     doi:10.1128/JB.187.14.5044-5048.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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