Journal of Bacteriology, August 2005, p. 5500-5503, Vol. 187, No. 15
0021-9193/05/$08.00+0 doi:10.1128/JB.187.15.5500-5503.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Characterization of the Vibrio cholerae vceCAB Multiple-Drug Resistance Efflux Operon in Escherichia coli
Robin C. Woolley,1
Govindsamy Vediyappan,2
Matthew Anderson,2
Melinda Lackey,2
Bhagavathi Ramasubramanian,2
Bai Jiangping,2
Tatyana Borisova,2
Jane A. Colmer,2
Abdul N. Hamood,2
Catherine S. McVay,3 and
Joe A. Fralick2*
Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409,1
Department of Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430,2
Department of Biological Sciences, Auburn University, Auburn, Alabama 368493
Received 30 March 2005/
Accepted 13 May 2005
Herein, we identify vceC as a component of a vceCAB operon, which codes for the Vibrio cholerae VceAB multiple-drug resistance (MDR) efflux pump, and vceR, which codes for a transcriptional autoregulatory protein that negatively regulates the expression of the vceCAB operon and is modulated by some of the substrates of this MDR efflux pump.
* Corresponding author. Mailing address: Department of Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430. Phone: (806) 743-2555. Fax: (806) 743-2334. E-mail: joe.fralick{at}ttuhsc.edu.
Journal of Bacteriology, August 2005, p. 5500-5503, Vol. 187, No. 15
0021-9193/05/$08.00+0 doi:10.1128/JB.187.15.5500-5503.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
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Copyright © 2005 by the American Society for Microbiology. All rights reserved.