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Journal of Bacteriology, August 2005, p. 5837-5840, Vol. 187, No. 16
0021-9193/05/$08.00+0     doi:10.1128/JB.187.16.5837-5840.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Rv2358 and FurB: Two Transcriptional Regulators from Mycobacterium tuberculosis Which Respond to Zinc

Dipartimento di Genetica e Microbiologia, Università di Pavia, Pavia,¹ Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche, Università di Padova, Padua, Italy²

Received 26 November 2004/ Accepted 23 May 2005

In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc²155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn²⁺ ions.

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