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Journal of Bacteriology, August 2005, p. 5837-5840, Vol. 187, No. 16
0021-9193/05/$08.00+0     doi:10.1128/JB.187.16.5837-5840.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Rv2358 and FurB: Two Transcriptional Regulators from Mycobacterium tuberculosis Which Respond to Zinc

Fabio Canneva,1 Manuela Branzoni,1 Giovanna Riccardi,1 Roberta Provvedi,2 and Anna Milano1*

Dipartimento di Genetica e Microbiologia, Università di Pavia, Pavia,1 Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche, Università di Padova, Padua, Italy2

Received 26 November 2004/ Accepted 23 May 2005

In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc2155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn2+ ions.

* Corresponding author. Mailing address: Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, via Ferrata 1, 27100 Pavia, Italy. Phone: 00 39 (382) 985580. Fax: 00 39 (382) 528496. E-mail: a.milano{at}ipvgen.unipv.it.

Journal of Bacteriology, August 2005, p. 5837-5840, Vol. 187, No. 16
0021-9193/05/$08.00+0     doi:10.1128/JB.187.16.5837-5840.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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