Previous Article | Next Article 
Journal of Bacteriology, August 2005, p. 5837-5840, Vol. 187, No. 16
0021-9193/05/$08.00+0 doi:10.1128/JB.187.16.5837-5840.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Rv2358 and FurB: Two Transcriptional Regulators from Mycobacterium tuberculosis Which Respond to Zinc
Fabio Canneva,1
Manuela Branzoni,1
Giovanna Riccardi,1
Roberta Provvedi,2 and
Anna Milano1*
Dipartimento di Genetica e Microbiologia, Università di Pavia, Pavia,1
Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche, Università di Padova, Padua, Italy2
Received 26 November 2004/
Accepted 23 May 2005
In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc2155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn2+ ions.
* Corresponding author. Mailing address: Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, via Ferrata 1, 27100 Pavia, Italy. Phone: 00 39 (382) 985580. Fax: 00 39 (382) 528496. E-mail: a.milano{at}ipvgen.unipv.it.
Journal of Bacteriology, August 2005, p. 5837-5840, Vol. 187, No. 16
0021-9193/05/$08.00+0 doi:10.1128/JB.187.16.5837-5840.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
This article has been cited by other articles:
-
Campbell, D. R., Chapman, K. E., Waldron, K. J., Tottey, S., Kendall, S., Cavallaro, G., Andreini, C., Hinds, J., Stoker, N. G., Robinson, N. J., Cavet, J. S.
(2007). Mycobacterial Cells Have Dual Nickel-Cobalt Sensors: SEQUENCE RELATIONSHIPS AND METAL SITES OF METAL-RESPONSIVE REPRESSORS ARE NOT CONGRUENT. J. Biol. Chem.
282: 32298-32310
[Abstract]
[Full Text]
-
Shin, J.-H., Oh, S.-Y., Kim, S.-J., Roe, J.-H.
(2007). The Zinc-Responsive Regulator Zur Controls a Zinc Uptake System and Some Ribosomal Proteins in Streptomyces coelicolor A3(2). J. Bacteriol.
189: 4070-4077
[Abstract]
[Full Text]
-
Lucarelli, D., Russo, S., Garman, E., Milano, A., Meyer-Klaucke, W., Pohl, E.
(2007). Crystal Structure and Function of the Zinc Uptake Regulator FurB from Mycobacterium tuberculosis. J. Biol. Chem.
282: 9914-9922
[Abstract]
[Full Text]
-
Maciag, A., Dainese, E., Rodriguez, G. M., Milano, A., Provvedi, R., Pasca, M. R., Smith, I., Palu, G., Riccardi, G., Manganelli, R.
(2007). Global Analysis of the Mycobacterium tuberculosis Zur (FurB) Regulon. J. Bacteriol.
189: 730-740
[Abstract]
[Full Text]
-
Grover, A., Sharma, R.
(2006). Identification and Characterization of a Major Zn(II) Resistance Determinant of Mycobacterium smegmatis.. J. Bacteriol.
188: 7026-7032
[Abstract]
[Full Text]
Copyright © 2005 by the American Society for Microbiology. All rights reserved.