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Journal of Bacteriology, September 2005, p. 6238-6241, Vol. 187, No. 17
0021-9193/05/$08.00+0     doi:10.1128/JB.187.17.6238-6241.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Implications of Physiological Studies Based on Genomic Sequences: Streptococcus pneumoniae TIGR4 Synthesizes a Functional LytC Lysozyme

Miriam Moscoso, Elena López,{dagger} Ernesto García, and Rubens López*

Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain

Received 31 March 2005/ Accepted 13 June 2005

The Streptococcus pneumoniae LytC lysozyme is responsible for autolysis at 30°C (a temperature close to that of the upper respiratory tract), promotes DNA release in competent cultures, and participates in nasopharyngeal colonization. We show that the virulent pneumococcal TIGR4 strain encodes an active LytC enzyme, in contrast with genome-based predictions.

* Corresponding author. Mailing address: Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain. Phone: (34) 91 837 3112. Fax: (34) 91 536 0432. E-mail: ruben{at}cib.csic.es.

{dagger} Present address: Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Campus de la Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Journal of Bacteriology, September 2005, p. 6238-6241, Vol. 187, No. 17
0021-9193/05/$08.00+0     doi:10.1128/JB.187.17.6238-6241.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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