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OpsX from Haemophilus influenzae Represents a Novel Type of Heptosyltransferase I in Lipopolysaccharide Biosynthesis

Sabine Gronow,^1* Werner Brabetz,^1, Buko Lindner,² and Helmut Brade¹

Divisions of Medical and Biochemical Microbiology,¹ Biophysics, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Parkallee 22, D-23845 Borstel, Germany²

Received 1 April 2005/ Accepted 26 May 2005

The inner core region of the lipopolysaccharide (LPS) of Haemophilus influenzae is characterized by the presence of a phosphorylated 3-deoxy--D-manno-octulosonic acid (Kdo). In this study, we show that the heptosyltransferase I adding the first L-glycero-D-manno-heptose residue to this acceptor is encoded by the gene opsX, which differs in substrate specificity from the other heptosyltransferase I, known as WaaC.

Present address: Biotype AG, Moritzburger Weg 67, D-01109 Dresden, Germany.

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