This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Calmann, M. A. Articles by Marinus, M. G. Search for Related Content PubMed PubMed Citation Articles by Calmann, M. A. Articles by Marinus, M. G.

The MutS C Terminus Is Essential for Mismatch Repair Activity In Vivo

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605

Received 17 May 2005/ Accepted 20 June 2005

An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutS800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, antirecombination, and sensitivity to cytotoxic agents in a dam mutant background.

This article has been cited by other articles:

• Mendillo, M. L., Putnam, C. D., Kolodner, R. D. (2007). Escherichia coli MutS Tetramerization Domain Structure Reveals That Stable Dimers but Not Tetramers Are Essential for DNA Mismatch Repair in Vivo. J. Biol. Chem. 282: 16345-16354 [Abstract] [Full Text]  
• Manelyte, L., Urbanke, C., Giron-Monzon, L., Friedhoff, P. (2006). Structural and functional analysis of the MutS C-terminal tetramerization domain. Nucleic Acids Res 34: 5270-5279 [Abstract] [Full Text]  
• de Saro, F. J. L., Marinus, M. G., Modrich, P., O'Donnell, M. (2006). The beta Sliding Clamp Binds to Multiple Sites within MutL and MutS. J. Biol. Chem. 281: 14340-14349 [Abstract] [Full Text]