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Journal of Bacteriology, September 2005, p. 6599-6600, Vol. 187, No. 18
0021-9193/05/$08.00+0     doi:10.1128/JB.187.18.6599-6600.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Yersinia pestis Is Viable with Endotoxin Composed of Only Lipid A

Li Tan and Creg Darby*

Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294

Received 28 April 2005/ Accepted 21 June 2005

Lipopolysaccharide (LPS) is the major outer membrane component of gram-negative bacteria. The minimal LPS structure for viability of Escherichia coli and Salmonella enterica serovar Typhimurium is lipid A glycosylated with 3-deoxy-D-manno-octulosonic acid (Kdo) residues. Here we show that another member of the Enterobacteriaceae, Yersinia pestis, can survive without Kdo in its LPS.

* Corresponding author. Mailing address: Department of Microbiology, University of Alabama at Birmingham, BBRB Box 19, 1530 3rd Avenue South, Birmingham, AL 35294-2170. Phone: (205) 934-3836. Fax: (205) 996-7888. E-mail: creg{at}uab.edu.

Journal of Bacteriology, September 2005, p. 6599-6600, Vol. 187, No. 18
0021-9193/05/$08.00+0     doi:10.1128/JB.187.18.6599-6600.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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