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Regulation of sigL Expression by the Catabolite Control Protein CcpA Involves a Roadblock Mechanism in Bacillus subtilis: Potential Connection between Carbon and Nitrogen Metabolism

Soo-Keun Choi and Milton H. Saier Jr.^*

Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116

Received 4 April 2005/ Accepted 14 July 2005

A catabolite-responsive element (CRE), a binding site for the CcpA transcription factor, was identified within the sigL structural gene encoding ^L in Bacillus subtilis. We show that CcpA binds to this CRE to regulate sigL expression by a "roadblock" mechanism and that this mechanism in part accounts for catabolite repression of ^L-directed levD operon expression.

Permanent address: Laboratory of Microbial Genomics, Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oundong, Yusong, Daejeon 305-333, Korea.

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