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Journal of Bacteriology, October 2005, p. 6856-6861, Vol. 187, No. 19
0021-9193/05/$08.00+0     doi:10.1128/JB.187.19.6856-6861.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Regulation of sigL Expression by the Catabolite Control Protein CcpA Involves a Roadblock Mechanism in Bacillus subtilis: Potential Connection between Carbon and Nitrogen Metabolism

Soo-Keun Choi{dagger} and Milton H. Saier Jr.*

Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116

Received 4 April 2005/ Accepted 14 July 2005

A catabolite-responsive element (CRE), a binding site for the CcpA transcription factor, was identified within the sigL structural gene encoding {sigma}L in Bacillus subtilis. We show that CcpA binds to this CRE to regulate sigL expression by a "roadblock" mechanism and that this mechanism in part accounts for catabolite repression of {sigma}L-directed levD operon expression.

* Corresponding author. Mailing address: Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116. Phone: (858) 534-4084. Fax: (858) 534-7108. E-mail: msaier{at}ucsd.edu.

{dagger} Permanent address: Laboratory of Microbial Genomics, Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oundong, Yusong, Daejeon 305-333, Korea.

Journal of Bacteriology, October 2005, p. 6856-6861, Vol. 187, No. 19
0021-9193/05/$08.00+0     doi:10.1128/JB.187.19.6856-6861.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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