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Journal of Bacteriology, January 2005, p. 785-790, Vol. 187, No. 2
0021-9193/05/$08.00+0     doi:10.1128/JB.187.2.785-790.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The BpsIR Quorum-Sensing System of Burkholderia pseudomallei

Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore, Republic of Singapore

Received 1 March 2004/ Accepted 29 September 2004

BpsIR, a LuxIR quorum-sensing homolog, is required for optimal expression of virulence and secretion of exoproducts in Burkholderia pseudomallei. Cell density-dependent expression of bpsI and bpsR, the positive regulation of bpsIR expression by BpsR, and the synthesis of N-octanoyl-homoserine lactone (C8HSL) by BpsI are described in this report.

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