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Journal of Bacteriology, October 2005, p. 7155-7160, Vol. 187, No. 20
0021-9193/05/$08.00+0     doi:10.1128/JB.187.20.7155-7160.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

YrxA Is the Transcriptional Regulator That Represses De Novo NAD Biosynthesis in Bacillus subtilis

Paola Rossolillo, Ilaria Marinoni, Elisa Galli, Anna Colosimo, and Alessandra M. Albertini^*

Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, Pavia, Italy

Received 22 June 2005/ Accepted 2 August 2005

The first genetic, in vivo, and in vitro evidences that YrxA is the regulator of NAD de novo biosynthesis in Bacillus subtilis are hereby reported. The protein is essential to the transcription repression of the divergent operons nadBCA and nifS-yrxA in the presence of nicotinic acid and binds to their shared operator-promoter region.

Present address: Dipartimento Materno Infantile e di Biologia-Genetica, Università di Verona, Verona, Italy.

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