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Tryptophan Catabolism: Identification and Characterization of a New Degradative Pathway

Department of Chemistry, Muhlenberg College, 2400 Chew Street, Allentown, Pennsylvania 18104,¹ Department of Chemistry and Chemical Biology, 120 Baker Laboratory, Cornell University, Ithaca, New York 14853²

Received 4 June 2005/ Accepted 24 August 2005

A new tryptophan catabolic pathway is characterized from Burkholderia cepacia J2315. In this pathway, tryptophan is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvate and acetate via the intermediates 2-aminomuconate and 4-oxalocrotonate. This pathway differs from the proposed mammalian pathway which converts 2-aminomuconate to 2-ketoadipate and, ultimately, glutaryl-coenzyme A.

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