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CspA Regulates Pigment Production in Staphylococcus aureus through a SigB-Dependent Mechanism

Samuel Katzif ,^1,3,, Eun-Hee Lee,^1,3, Anthony B. Law,^1,3 Yih-Ling Tzeng,² and William M. Shafer^1,2,3*

Departments of Microbiology and Immunology,¹ Medicine, Emory University School of Medicine, Atlanta, Georgia 30322,² Laboratories of Bacterial Pathogenesis, Medical Research Service, VA Medical Center, Decatur, Georgia 30033³

Received 16 June 2005/ Accepted 15 September 2005

We report that the cold shock protein CspA of Staphylococcus aureus is required for maximal production of pigment. Results from transcriptional studies revealed that loss of CspA resulted in decreased expression of genes needed for the biosynthesis of 4,4'-diaponeurosporene and the alternative sigma factor SigB.

Present address: Midwestern University, Glendale, AZ 85308.

These authors contributed equally to this work.

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