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Journal of Bacteriology, December 2005, p. 8201-8204, Vol. 187, No. 23
0021-9193/05/$08.00+0     doi:10.1128/JB.187.23.8201-8204.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Second Case of –1 Ribosomal Frameshifting Affecting a Major Virion Protein of the Lactobacillus Bacteriophage A2

Isabel Rodríguez, Pilar García, and Juan E. Suárez*

Area de Microbiología, Instituto Universitario de Biotecnología (IUBA), Universidad de Oviedo and Instituto de Productos Lácteos de Asturias (CSIC), Villaviciosa, Spain

Received 23 June 2005/ Accepted 12 September 2005

The bacteriophage A2 major tail protein gene utilizes a –1 translational frameshift to generate two structural polypeptides. Frameshifting is promoted by a slippery sequence and an RNA pseudoknot located 3' of the gene. The major head gene presents a similar recoding ability. A2 is the only phage described with two –1 frameshifts.

* Corresponding author. Mailing address: Area de Microbiología, Facultad de Medicina, Universidad de Oviedo, Julián Clavería 6, 33006 Oviedo, Spain. Phone: 34-985103559. Fax: 34-985103148. E-mail: evaristo{at}uniovi.es.

Journal of Bacteriology, December 2005, p. 8201-8204, Vol. 187, No. 23
0021-9193/05/$08.00+0     doi:10.1128/JB.187.23.8201-8204.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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