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Journal of Bacteriology, December 2005, p. 8205-8210, Vol. 187, No. 23
0021-9193/05/$08.00+0     doi:10.1128/JB.187.23.8205-8210.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Vancomycin Stress Response in a Sensitive and a Tolerant Strain of Streptococcus pneumoniae

Wolfgang Haas,1* Deepak Kaushal,2 Jack Sublett,1 Caroline Obert,1 and Elaine I. Tuomanen1

Departments of Infectious Diseases,1 Functional Genomics, Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee2

Received 13 July 2005/ Accepted 15 September 2005

The vancomycin stress response was studied in Streptococcus pneumoniae strains T4 (TIGR4) and Tupelo. Vancomycin affected the expression of 175 genes, including genes encoding transport functions and enzymes involved in aminosugar metabolism. The two-component systems TCS03, TCS11, and CiaRH also responded to antibiotic treatment. We hypothesize that the three regulons are an important part of the bacterium's response to vancomycin stress.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Center for Oral Biology, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY 14642. Phone: (585) 275-7722. Fax: (585) 276-0190. E-mail: wolfgang_haas{at}urmc.rochester.edu.

Journal of Bacteriology, December 2005, p. 8205-8210, Vol. 187, No. 23
0021-9193/05/$08.00+0     doi:10.1128/JB.187.23.8205-8210.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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