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Journal of Bacteriology, December 2005, p. 8494-8498, Vol. 187, No. 24
0021-9193/05/$08.00+0     doi:10.1128/JB.187.24.8494-8498.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Shiga Toxin 1-Converting Bacteriophage BP-4795 Encodes an NleA-Like Type III Effector Protein

Kristina Creuzburg,^1, Jürgen Recktenwald,^2, Volker Kuhle,³ Sylvia Herold,^1, Michael Hensel,³ and Herbert Schmidt^4*

Institute of Medical Microbiology and Hygiene, Technical University of Dresden, 01307 Dresden, Germany,¹ Institute of Hygiene and Microbiology, University of Würzburg, 97070 Würzburg, Germany,² Institute of Clinical Microbiology, Immunology and Hygiene, FAU Erlangen-Nürnberg, 91054 Erlangen, Germany,³ Institute of Food Technology, Department of Food Microbiology, University of Hohenheim, 70599 Stuttgart, Germany⁴

Received 6 July 2005/ Accepted 21 September 2005

In this study, the complete DNA sequence of Shiga toxin 1-converting bacteriophage BP-4795 was determined. The genome of BP-4795 consists of 85 open reading frames, including two complete IS629 elements and three morons at the end of its late regulatory region. One of these morons encodes a type III effector that is translocated by the locus of enterocyte effacement-encoded type III secretion system into HeLa cells, where it localizes with the Golgi apparatus.

Present address: Institute of Food Technology, Department of Food Microbiology, University of Hohenheim, 70599 Stuttgart, Germany.

Present address: Phenion GmbH & CoKG, 60439 Frankfurt, Germany.

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